Review
doi: 10.1016/s0014-5793(03)00451-4.
MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation
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- PMID: 12829236
- DOI: 10.1016/s0014-5793(03)00451-4
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Review
MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation
FEBS Lett.
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Free article
Abstract
That signalling pathways, particularly the mitogen-activated protein kinase cascades, elicit modification of chromatin proteins such as histone H3 by phosphorylation and/or acetylation concomitant with gene activation is now well established. The picture that is emerging is one of a complex and dynamic pattern of multiple modifications at the H3 tail. Here, we review the inducible gene systems where H3 modifications have been reported and re-evaluate the controversy as to the kinase(s) that phosphorylates it as well as the proposed coupling between H3 phosphorylation and acetylation.
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