Review
doi: 10.1016/S0968-0004(03)00092-6.
A potential proteasome-interacting motif within the ubiquitin-like domain of parkin and other proteins
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- PMID: 12826399
- DOI: 10.1016/S0968-0004(03)00092-6
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Review
A potential proteasome-interacting motif within the ubiquitin-like domain of parkin and other proteins
Trends Biochem Sci.
2003 Jun.
Abstract
Parkin and other unrelated proteins contain a ubiquitin-like domain (UbLD). This article describes a motif that might be important in the interaction of UbLD-containing proteins (UbLPs) with the proteasome. The proteasome-interacting motif, which is conserved in a subset of UbLPs, such as parkin, Rad23 and several transcription factors, is likely to enable the UbLPs to form a complex with the proteasome for proteolysis or the recently discovered non-proteolytic functions of the proteasome.
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