Review
doi: 10.1126/science.1281928.
Biochemistry of nitric oxide and its redox-activated forms
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- PMID: 1281928
- DOI: 10.1126/science.1281928
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Review
Biochemistry of nitric oxide and its redox-activated forms
Science.
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Abstract
Nitric oxide (NO.), a potentially toxic molecule, has been implicated in a wide range of biological functions. Details of its biochemistry, however, remain poorly understood. The broader chemistry of nitrogen monoxide (NO) involves a redox array of species with distinctive properties and reactivities: NO+ (nitrosonium), NO., and NO- (nitroxyl anion). The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.
Comment in
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No lack of NO activity.Science. 1993 Apr 9;260(5105):145-6. Science. 1993. PMID: 8469963 No abstract available.
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