Review
doi: 10.1016/0952-7915(92)90051-f.
Non-MHC-linked genes in autoimmune diseases
Affiliations
- PMID: 1281639
- DOI: 10.1016/0952-7915(92)90051-f
Item in Clipboard
Review
Non-MHC-linked genes in autoimmune diseases
Curr Opin Immunol.
1992 Dec.
Abstract
The gene responsible for the lpr mutation in MRL mice that are prone to systemic lupus erythematosus has been shown to encode the apoptosis-inducing Fas antigen, thus pointing to control of apoptosis as a major regulatory mechanism in autoimmunity. In the non-obese diabetic mouse model for insulin-dependent diabetes, four non-MHC-linked loci have been localized in the murine genome that were found to be associated with successive stages of the disease. These findings should soon have a major impact on our understanding of human autoimmune diseases.
Similar articles
-
Spontaneous autoimmune skin lesions of MRL/n mice: autoimmune disease-prone genetic background in relation to Fas-defect MRL/1pr mice.J Invest Dermatol. 1996 Jul;107(1):95-100. doi: 10.1111/1523-1747.ep12298305. J Invest Dermatol. 1996. PMID: 8752846
-
Autoimmune diabetes-prone NOD mice express the Lyt2 alpha (Lyt2.1) and Lyt3 alpha (Lyt3.1) alleles of CD8.Immunogenetics. 1996;43(1-2):6-12. doi: 10.1007/BF00186598. Immunogenetics. 1996. PMID: 8537123
-
A defect in central tolerance in NOD mice.Nat Immunol. 2001 Nov;2(11):1025-31. doi: 10.1038/ni726. Nat Immunol. 2001. PMID: 11668341
-
Non-MHC-linked genes in autoimmune diseases.Curr Opin Immunol. 1993 Dec;5(6):894-9. doi: 10.1016/0952-7915(93)90102-x. Curr Opin Immunol. 1993. PMID: 8297521 Review.
-
The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane.Immunol Today. 1992 Nov;13(11):427-8. doi: 10.1016/0167-5699(92)90066-G. Immunol Today. 1992. PMID: 1282318 Review.
Cited by
-
Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity.Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5898-902. doi: 10.1073/pnas.91.13.5898. Proc Natl Acad Sci U S A. 1994. PMID: 8016086 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous
