Hepatoma derived growth factor is a nuclear targeted mitogen
- PMID: 12816346
- DOI: 10.2174/1389450033490975
Hepatoma derived growth factor is a nuclear targeted mitogen
Abstract
Hepatoma Derived Growth Factor (HDGF) was originally identified as a secreted mitogen from the human hepatoma cell line Huh-7. Although initially thought to be a cytoplasmic protein, it became clear that HDGF is a nuclear targeted protein containing a canonical bipartite nuclear localization sequence. In the developing vasculature HDGF is highly expressed in the nucleus of smooth muscle and endothelial cells. HDGF expression in smooth muscle in particular, declines after birth in larger arteries only to be re-expressed with vascular injury in cells of the highly proliferative neointima. In addition, levels of HDGF have recently been shown to be elevated in a number of cancers, suggesting a potential role in cancer development. Because of these roles, HDGF is a potential target for drug design. This review will describe current knowledge about the biochemical functioning of the protein and identify potential avenues for drug development.
Similar articles
-
Hepatoma-derived growth factor is expressed after vascular injury in the rat and stimulates smooth muscle cell migration.Pediatr Res. 2006 Jun;59(6):778-83. doi: 10.1203/01.pdr.0000219299.24435.4f. Epub 2006 Apr 26. Pediatr Res. 2006. PMID: 16641209
-
Nuclear targeting is required for hepatoma-derived growth factor-stimulated mitogenesis in vascular smooth muscle cells.J Biol Chem. 2001 Oct 5;276(40):37564-8. doi: 10.1074/jbc.M105109200. Epub 2001 Jul 31. J Biol Chem. 2001. PMID: 11481329
-
Hepatoma-derived growth factor stimulates smooth muscle cell growth and is expressed in vascular development.J Clin Invest. 2000 Mar;105(5):567-75. doi: 10.1172/JCI7497. J Clin Invest. 2000. PMID: 10712428 Free PMC article.
-
Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of Hepatocellular Carcinoma.Int J Mol Sci. 2015 Jun 19;16(6):14086-97. doi: 10.3390/ijms160614086. Int J Mol Sci. 2015. PMID: 26101867 Free PMC article. Review.
-
Hepatoma-Derived Growth Factor: An Overview and Its Role as a Potential Therapeutic Target Molecule for Digestive Malignancies.Int J Mol Sci. 2020 Jun 13;21(12):4216. doi: 10.3390/ijms21124216. Int J Mol Sci. 2020. PMID: 32545762 Free PMC article. Review.
Cited by
-
Mass spectrometry-based proteomic analysis of the matrix microenvironment in pluripotent stem cell culture.Mol Cell Proteomics. 2012 Dec;11(12):1924-36. doi: 10.1074/mcp.M112.020057. Epub 2012 Sep 27. Mol Cell Proteomics. 2012. PMID: 23023296 Free PMC article.
-
Upregulation of nucleus HDGF predicts poor prognostic outcome in patients with penile squamous cell carcinoma bypass VEGF-A and Ki-67.Med Oncol. 2013 Dec;30(4):702. doi: 10.1007/s12032-013-0702-9. Epub 2013 Sep 3. Med Oncol. 2013. PMID: 23999841
-
Prognostic significance of nuclear hepatoma-derived growth factor expression in gallbladder cancer.World J Gastroenterol. 2014 Jul 28;20(28):9564-9. doi: 10.3748/wjg.v20.i28.9564. World J Gastroenterol. 2014. PMID: 25071353 Free PMC article.
-
Identification of interactive molecules between antler stem cells and dermal papilla cells using an in vitro co-culture system.J Mol Histol. 2020 Feb;51(1):15-31. doi: 10.1007/s10735-019-09853-9. Epub 2019 Dec 19. J Mol Histol. 2020. PMID: 31858326
-
Hepatoma-derived growth factor: a novel prognostic biomarker in intrahepatic cholangiocarcinoma.Tumour Biol. 2015 Jan;36(1):353-64. doi: 10.1007/s13277-014-2651-0. Epub 2014 Sep 28. Tumour Biol. 2015. PMID: 25262276
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources