Comment
doi: 10.1073/pnas.1432875100.
Epub 2003 Jun 16.
Replication of the herpes simplex virus genome: does it really go around in circles?
Affiliations
- PMID: 12810944
- PMCID: PMC164601
- DOI: 10.1073/pnas.1432875100
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Comment
Replication of the herpes simplex virus genome: does it really go around in circles?
Proc Natl Acad Sci U S A.
.
No abstract available
Figures
Schematic representation of the HSV-1 genome showing the unique long region (UL) bounded by a terminal repeat region (TRL) and an inverted internal repeat region (IRL). The unique short region (US) is similarly bounded by a terminal repeat region (TRS) and an inverted internal repeat region (IRS). The three origins of DNA replication, oriL and two copies of oriS, are shown. Jackson and DeLuca (16) have shown that, in the absence of ICP0, the genome circularizes and persists. When ICP0 is expressed very early during infection, the genome replicates and both linear and concatemeric replication forms are detected. Thus, these authors suggest that ICP0 regulates circle formation, and that circle formation may lead to latency, whereas DNA replication during productive infection prefers a linear template.
Comment on
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Relationship of herpes simplex virus genome configuration to productive and persistent infections.Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7871-6. doi: 10.1073/pnas.1230643100. Epub 2003 Jun 9. Proc Natl Acad Sci U S A. 2003. PMID: 12796511 Free PMC article.
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