The use of DNA microarrays to assess clinical samples: the transition from bedside to bench to bedside
- PMID: 12795413
- DOI: 10.1210/rp.58.1.25
The use of DNA microarrays to assess clinical samples: the transition from bedside to bench to bedside
Abstract
The advent of gene array technology brings the ability to classify disease states to the molecular level by examining changes in all mRNAs expressed in cells or tissues. Comparing changes in gene expression patterns between normal and diseased cells and/or tissues has elucidated unique subsets of genes identifiable to a specific disease. Already, new subclassifications of specific cancers have been discovered, belying that genomic profiling can uniquely distinguish a specific disease state and tissue of origin. This technology bestows the ability to examine global changes occurring in a cell or tissue(s), thereby allowing the elucidation of alterations in dysregulated biological, biochemical, and molecular events leading to disease states such as diabetes, hypertension, infertility, obesity, osteoporosis, and atherosclerosis. Furthermore, genomic profiling will lead to new molecular targets for the development of drug therapeutics. Futuristically, one could envision personalized patient therapies based upon identification of specific aberrant signaling pathways that can be targeted for drug therapy.
Similar articles
-
Multiplexed, targeted gene expression profiling and genetic analysis on electronic microarrays.Clin Chem. 2002 Nov;48(11):1873-82. Clin Chem. 2002. PMID: 12406971
-
[DNA microarrays--perspective of application for drug effectivity and safety evaluation].Postepy Biochem. 2008;54(1):107-15. Postepy Biochem. 2008. PMID: 18610588 Review. Polish.
-
Microarray expression profiling in adhesion and normal peritoneal tissues.Fertil Steril. 2012 May;97(5):1158-64.e1-4. doi: 10.1016/j.fertnstert.2012.02.001. Epub 2012 Feb 22. Fertil Steril. 2012. PMID: 22365381
-
Array comparative genomic hybridization copy number profiling: a new tool for translational research in solid malignancies.Semin Radiat Oncol. 2008 Apr;18(2):98-104. doi: 10.1016/j.semradonc.2007.10.005. Semin Radiat Oncol. 2008. PMID: 18314064 Review.
-
Technology evaluation: SAGE, Genzyme molecular oncology.Curr Opin Mol Ther. 2001 Feb;3(1):85-96. Curr Opin Mol Ther. 2001. PMID: 11249736 Review.
Cited by
-
Characterization of visceral and subcutaneous adipose tissue transcriptome in pregnant women with and without spontaneous labor at term: implication of alternative splicing in the metabolic adaptations of adipose tissue to parturition.J Perinat Med. 2016 Oct 1;44(7):813-835. doi: 10.1515/jpm-2015-0259. J Perinat Med. 2016. PMID: 26994472 Free PMC article.
-
A gene expression signature from peripheral whole blood for stage I lung adenocarcinoma.Cancer Prev Res (Phila). 2011 Oct;4(10):1599-608. doi: 10.1158/1940-6207.CAPR-10-0170. Epub 2011 Jul 8. Cancer Prev Res (Phila). 2011. PMID: 21742797 Free PMC article.
-
Complex genetics of obesity in mouse models.Annu Rev Nutr. 2008;28:331-45. doi: 10.1146/annurev.nutr.27.061406.093552. Annu Rev Nutr. 2008. PMID: 18435591 Free PMC article. Review.
-
Validation and quality control of protein microarray-based analytical methods.Mol Biotechnol. 2008 Jan;38(1):19-31. doi: 10.1007/s12033-007-0066-5. Epub 2007 Aug 3. Mol Biotechnol. 2008. PMID: 18095188 Review.
-
Comparative Analysis of Shapley Values Enhances Transcriptomics Insights across Some Common Uterine Pathologies.Genes (Basel). 2024 Jun 1;15(6):723. doi: 10.3390/genes15060723. Genes (Basel). 2024. PMID: 38927658 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Other Literature Sources