Review
doi: 10.1038/ncb0603-505.
Polar expeditions--provisioning the centrosome for mitosis
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- PMID: 12776127
- DOI: 10.1038/ncb0603-505
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Review
Polar expeditions--provisioning the centrosome for mitosis
Nat Cell Biol.
2003 Jun.
Abstract
It is now clear that both centrioles and their surrounding pericentriolar material (PCM) are capable of self-assembly. Whereas centrioles are normally duplicated during G1-S phase, PCM components may be loaded onto centrosomes in both a microtubule-dependent and -independent manner at all stages of the cell cycle. Centrosomes enlarge dramatically after mitotic entry, when both Aurora A and Polo-like kinases cooperate to recruit additional gamma-tubulin ring complexes and microtubule-associated proteins to assist spindle formation.
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