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Review
. 2003 May;15(3):179-84.
doi: 10.1097/00002281-200305000-00002.

Infectious complications of biologic treatments of rheumatoid arthritis

Aparna K Mohan  1 , Timothy R Coté, Jeffrey N Siegel, M Miles Braun
Affiliations
Review

Infectious complications of biologic treatments of rheumatoid arthritis

Aparna K Mohan et al. Curr Opin Rheumatol. 2003 May.

Abstract

Agents that block the action of tumor necrosis factor-alpha and recombinant interleukin-1 have been shown to be effective biologic treatment modalities in patients with rheumatoid arthritis. Given the immunosuppressive effects of tumor necrosis factor-alpha and interleukin-1 blockers, infections have emerged as possible complications of using these agents, an observation foreshadowed in prelicensure animal studies. At this time, hundreds of thousands of patients have received these drugs, and a wide variety of infectious complications has been reported, among which reactivation tuberculosis is most notable. Case reports alone, however, do not necessarily reflect a causal association between a therapeutic product and an adverse event. The authors review the infectious complications of the use of these agents as reported in the medical literature from November 2001 through October 2002.

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