Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Apr 1;170(7):3528-33.
doi: 10.4049/jimmunol.170.7.3528.

The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs

Derry C Roopenian  1 , Gregory J Christianson, Thomas J Sproule, Aaron C Brown, Shreeram Akilesh, Nadja Jung, Stefka Petkova, Lia Avanessian, Eun Young Choi, Daniel J Shaffer, Peter A Eden, Clark L Anderson
Affiliations

The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs

Derry C Roopenian et al. J Immunol. .

Abstract

Abs of the IgG isotype are efficiently transported from mother to neonate and have an extended serum t(1/2) compared with Abs of other isotypes. Circumstantial evidence suggests that the MHC class I-related protein, the neonatal FcR (FcRn), is the FcR responsible for both in vivo functions. To understand the phenotypes imposed by FcRn, we produced and analyzed mice with a defective FcRn gene. The results provide direct evidence that perinatal IgG transport and protection of IgG from catabolism are mediated by FcRn, and that the latter function is key to IgG homeostasis, essential for generating a potent IgG response to foreign Ags, and the basis of enhanced efficacy of Fc-IgG-based therapeutics. FcRn is therefore a promising therapeutic target for enhancing protective humoral immunity, treating autoimmune disease, and improving drug efficacy.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics.
    Sand KM, Bern M, Nilsen J, Noordzij HT, Sandlie I, Andersen JT. Sand KM, et al. Front Immunol. 2015 Jan 26;5:682. doi: 10.3389/fimmu.2014.00682. eCollection 2014. Front Immunol. 2015. PMID: 25674083 Free PMC article. Review.
  • Generation and Characterization of an IgG4 Monomeric Fc Platform.
    Shan L, Colazet M, Rosenthal KL, Yu XQ, Bee JS, Ferguson A, Damschroder MM, Wu H, Dall'Acqua WF, Tsui P, Oganesyan V. Shan L, et al. PLoS One. 2016 Aug 1;11(8):e0160345. doi: 10.1371/journal.pone.0160345. eCollection 2016. PLoS One. 2016. PMID: 27479095 Free PMC article.
  • Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
    Franceschini N, van Rooij FJ, Prins BP, Feitosa MF, Karakas M, Eckfeldt JH, Folsom AR, Kopp J, Vaez A, Andrews JS, Baumert J, Boraska V, Broer L, Hayward C, Ngwa JS, Okada Y, Polasek O, Westra HJ, Wang YA, Del Greco M F, Glazer NL, Kapur K, Kema IP, Lopez LM, Schillert A, Smith AV, Winkler CA, Zgaga L; LifeLines Cohort Study; Bandinelli S, Bergmann S, Boban M, Bochud M, Chen YD, Davies G, Dehghan A, Ding J, Doering A, Durda JP, Ferrucci L, Franco OH, Franke L, Gunjaca G, Hofman A, Hsu FC, Kolcic I, Kraja A, Kubo M, Lackner KJ, Launer L, Loehr LR, Li G, Meisinger C, Nakamura Y, Schwienbacher C, Starr JM, Takahashi A, Torlak V, Uitterlinden AG, Vitart V, Waldenberger M, Wild PS, Kirin M, Zeller T, Zemunik T, Zhang Q, Ziegler A, Blankenberg S, Boerwinkle E, Borecki IB, Campbell H, Deary IJ, Frayling TM, Gieger C, Harris TB, Hicks AA, Koenig W, O' Donnell CJ, Fox CS, Pramstaller PP, Psaty BM, Reiner AP, Rotter JI, Rudan I, Snieder H, Tanaka T, van Duijn CM, Vollenweider P, Waeber G, Wilson JF, Witteman JC, Wolffenbuttel BH, Wright AF, Wu Q, Liu Y, Jenny NS, North KE, Felix JF, Alizadeh BZ, Cupples LA, Perry JR, Morris AP. Franceschini N, et al. Am J Hum Genet. 2012 Oct 5;91(4):744-53. doi: 10.1016/j.ajhg.2012.08.021. Epub 2012 Sep 27. Am J Hum Genet. 2012. PMID: 23022100 Free PMC article.
  • Monoclonal antibodies directed against human FcRn and their applications.
    Christianson GJ, Sun VZ, Akilesh S, Pesavento E, Proetzel G, Roopenian DC. Christianson GJ, et al. MAbs. 2012 Mar-Apr;4(2):208-16. doi: 10.4161/mabs.4.2.19397. Epub 2012 Mar 1. MAbs. 2012. PMID: 22453095 Free PMC article.
  • The Neonatal Fc Receptor (FcRn): A Misnomer?
    Pyzik M, Sand KMK, Hubbard JJ, Andersen JT, Sandlie I, Blumberg RS. Pyzik M, et al. Front Immunol. 2019 Jul 10;10:1540. doi: 10.3389/fimmu.2019.01540. eCollection 2019. Front Immunol. 2019. PMID: 31354709 Free PMC article. Review.
See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources