Nipah virus outbreak in Malaysia
- PMID: 12637075
- DOI: 10.1016/s1386-6532(02)00268-8
Nipah virus outbreak in Malaysia
Abstract
Nipah virus, a novel paramyxovirus, closely related to Hendra virus emerged in northern part of Peninsular Malaysia in 1998. The virus caused an outbreak of severe febrile encephalitis in humans with a high mortality rate, whereas, in pigs, encephalitis and respiratory diseases but with a relatively low mortality rate. The outbreak subsequently spread to various regions of the country and Singapore in the south due to the movement of infected pigs. Nipah virus caused systemic infections in humans, pigs and other mammals. Histopathological and radiological findings were characteristic of the disease. Fruitbats of Pteropid species were identified as the natural reservoir hosts. Evidence suggested that climatic and anthropogenic driven ecological changes coupled with the location of piggeries in orchard and the design of pigsties allowed the spill-over of this novel paramyxovirus from its reservoir host into the domestic pigs and ultimately to humans and other animals.
Similar articles
-
Anthropogenic deforestation, El Niño and the emergence of Nipah virus in Malaysia.Malays J Pathol. 2002 Jun;24(1):15-21. Malays J Pathol. 2002. PMID: 16329551
-
Nipah virus: a recently emergent deadly paramyxovirus.Science. 2000 May 26;288(5470):1432-5. doi: 10.1126/science.288.5470.1432. Science. 2000. PMID: 10827955
-
Emerging diseases. Malaysian researchers trace Nipah virus outbreak to bats.Science. 2000 Jul 28;289(5479):518-9. doi: 10.1126/science.289.5479.518. Science. 2000. PMID: 10939954
-
Epidemiology, surveillance and control of Nipah virus infections in Malaysia.Malays J Pathol. 2010 Dec;32(2):69-73. Malays J Pathol. 2010. PMID: 21329176 Review.
-
Nipah virus infection of pigs in peninsular Malaysia.Rev Sci Tech. 2000 Apr;19(1):160-5. doi: 10.20506/rst.19.1.1202. Rev Sci Tech. 2000. PMID: 11189713 Review.
Cited by
-
Comparison of the pathogenicity of Nipah virus isolates from Bangladesh and Malaysia in the Syrian hamster.PLoS Negl Trop Dis. 2013;7(1):e2024. doi: 10.1371/journal.pntd.0002024. Epub 2013 Jan 17. PLoS Negl Trop Dis. 2013. PMID: 23342177 Free PMC article.
-
Nipah virus infects specific subsets of porcine peripheral blood mononuclear cells.PLoS One. 2012;7(1):e30855. doi: 10.1371/journal.pone.0030855. Epub 2012 Jan 27. PLoS One. 2012. PMID: 22303463 Free PMC article.
-
Emerging infections in animals--potential new zoonoses?Clin Lab Med. 2004 Sep;24(3):825-38, viii. doi: 10.1016/j.cll.2004.05.001. Clin Lab Med. 2004. PMID: 15325066 Free PMC article. Review.
-
The pig as an amplifying host for new and emerging zoonotic viruses.One Health. 2022 Apr 1;14:100384. doi: 10.1016/j.onehlt.2022.100384. eCollection 2022 Jun. One Health. 2022. PMID: 35392655 Free PMC article. Review.
-
Biological characters of bats in relation to natural reservoir of emerging viruses.Comp Immunol Microbiol Infect Dis. 2007 Sep;30(5-6):357-74. doi: 10.1016/j.cimid.2007.05.006. Epub 2007 Aug 15. Comp Immunol Microbiol Infect Dis. 2007. PMID: 17706776 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
