Structural and functional relation of neuropilins
- PMID: 12613543
- DOI: 10.1007/978-1-4615-0119-0_5
Structural and functional relation of neuropilins
Abstract
Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologues, Neuropilin-1 and -2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a short cytoplasmic region. Both Neuropilin-1 and Neuropilin-2 have truncated and secreted form of splice variants. Neuropilins act as a receptor for two different extracellular ligands, class 3 semaphorins and specific isoforms of vascular endothelial growth factor. In both cases, neuropilin requires an additional transmembrane molecule to exhibit biological activity. Plexin-A is essential for class 3 semaphorin signaling. Vascular endothelial cell growth factor (VEGF) receptor is the major receptor for VEGF and neuropilin acts as isoform specific co-receptor for VEGF. The CUB and FV/FVIII domains of Neuropilin are the binding sites of semaphorin and VEGF. The MAM domain mediates semaphorin signaling to Plexin-A. Cross talk between semaphorin and VEGF on neuropilin suggests that class 3 semaphorins and the secreted forms of neuropilin act as antagonists to VEGF and its related growth factors.
Similar articles
-
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.EMBO J. 2007 Nov 28;26(23):4902-12. doi: 10.1038/sj.emboj.7601906. Epub 2007 Nov 8. EMBO J. 2007. PMID: 17989695 Free PMC article.
-
The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF.Adv Exp Med Biol. 2002;515:81-90. doi: 10.1007/978-1-4615-0119-0_7. Adv Exp Med Biol. 2002. PMID: 12613545 Review.
-
The function of neuropilin/plexin complexes.Adv Exp Med Biol. 2002;515:71-80. doi: 10.1007/978-1-4615-0119-0_6. Adv Exp Med Biol. 2002. PMID: 12613544 Review.
-
VEGF-A121a binding to Neuropilins - A concept revisited.Cell Adh Migr. 2018 May 4;12(3):204-214. doi: 10.1080/19336918.2017.1372878. Epub 2017 Nov 2. Cell Adh Migr. 2018. PMID: 29095088 Free PMC article. Review.
-
Transmembrane recognition of the semaphorin co-receptors neuropilin 1 and plexin A1: coarse-grained simulations.PLoS One. 2014 May 23;9(5):e97779. doi: 10.1371/journal.pone.0097779. eCollection 2014. PLoS One. 2014. PMID: 24858828 Free PMC article.
Cited by
-
Identification of circulating neuropilin-1 and dose-dependent elevation following anti-neuropilin-1 antibody administration.MAbs. 2009 Jul-Aug;1(4):364-9. doi: 10.4161/mabs.1.4.8885. Epub 2009 Jul 29. MAbs. 2009. PMID: 20068394 Free PMC article.
-
Molecular dynamics simulations, docking and MMGBSA studies of newly designed peptide-conjugated glucosyloxy stilbene derivatives with tumor cell receptors.Mol Divers. 2022 Oct;26(5):2717-2743. doi: 10.1007/s11030-021-10354-9. Epub 2022 Jan 17. Mol Divers. 2022. PMID: 35037187
-
Neuropilin-2 induced by transforming growth factor-β augments migration of hepatocellular carcinoma cells.BMC Cancer. 2015 Nov 16;15:909. doi: 10.1186/s12885-015-1919-0. BMC Cancer. 2015. PMID: 26573807 Free PMC article.
-
Semaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas.BMC Cancer. 2020 Dec 10;20(1):1213. doi: 10.1186/s12885-020-07694-4. BMC Cancer. 2020. PMID: 33302912 Free PMC article.
-
Effects of MLL5 and HOXA regulated by NRP1 on radioresistance in A549.Oncol Lett. 2021 May;21(5):403. doi: 10.3892/ol.2021.12664. Epub 2021 Mar 19. Oncol Lett. 2021. PMID: 33777226 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
