Polarised migration: cofilin holds the front
- PMID: 12593812
- DOI: 10.1016/s0960-9822(03)00072-1
Polarised migration: cofilin holds the front
Abstract
Persistent cell locomotion is a key feature of eukaryotic cells responding to diverse physiological cues. New work now directly implicates ADF/cofilin proteins as essential regulators of polarised cell migration.
Comment on
-
ADF/cofilin controls cell polarity during fibroblast migration.Curr Biol. 2003 Feb 4;13(3):252-7. doi: 10.1016/s0960-9822(03)00040-x. Curr Biol. 2003. PMID: 12573223
Similar articles
-
The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration.Dev Biol. 2005 Feb 1;278(1):231-41. doi: 10.1016/j.ydbio.2004.11.010. Dev Biol. 2005. PMID: 15649475
-
Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells.Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):6936-8. doi: 10.1073/pnas.97.13.6936. Proc Natl Acad Sci U S A. 2000. PMID: 10860951 Free PMC article. No abstract available.
-
Cofilin/ADF is required for cell motility during Drosophila ovary development and oogenesis.Nat Cell Biol. 2001 Feb;3(2):204-9. doi: 10.1038/35055120. Nat Cell Biol. 2001. PMID: 11175754
-
Accelerating on a treadmill: ADF/cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton.J Cell Biol. 1997 Mar 24;136(6):1165-8. doi: 10.1083/jcb.136.6.1165. J Cell Biol. 1997. PMID: 9087434 Free PMC article. Review. No abstract available.
-
Proteins of the ADF/cofilin family: essential regulators of actin dynamics.Annu Rev Cell Dev Biol. 1999;15:185-230. doi: 10.1146/annurev.cellbio.15.1.185. Annu Rev Cell Dev Biol. 1999. PMID: 10611961 Review.
Cited by
-
Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay.J Neurosci. 2012 Apr 11;32(15):5298-309. doi: 10.1523/JNEUROSCI.0227-12.2012. J Neurosci. 2012. PMID: 22496575 Free PMC article.
-
Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration.J Cell Biol. 2005 Oct 24;171(2):349-59. doi: 10.1083/jcb.200504029. Epub 2005 Oct 17. J Cell Biol. 2005. PMID: 16230460 Free PMC article.
-
Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding.J Cell Biol. 2008 Dec 1;183(5):865-79. doi: 10.1083/jcb.200804161. Epub 2008 Nov 24. J Cell Biol. 2008. PMID: 19029335 Free PMC article.
-
Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin-proteasome pathway.Oncogene. 2010 Jan 14;29(2):263-72. doi: 10.1038/onc.2009.319. Epub 2009 Oct 5. Oncogene. 2010. PMID: 19802004 Free PMC article.
-
PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion.J Cell Sci. 2010 May 15;123(Pt 10):1663-73. doi: 10.1242/jcs.055707. Epub 2010 Apr 20. J Cell Sci. 2010. PMID: 20406887 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials