TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction
- PMID: 12539043
- DOI: 10.1038/ni886
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction
Abstract
Human Toll-like receptor (TLR) 3 recognizes double-stranded (ds) RNA and induces production of interferon (IFN)-beta independent of the adaptor molecules MyD88 and TIRAP. Thus, another adaptor must exist that preferentially mediates TLR3-dependent production of IFN-beta. We have identified an alternative adaptor, designated Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule (TICAM)-1, that can physically bind the TIR domain of TLR3 and activate the IFN-beta promoter in response to poly(I):poly(C). Thus, dsRNA-TLR3-dependent production of IFN-beta is mediated mainly by TICAM-1. This TICAM-1-dependent pathway may have a role in other TLR-IFN-beta pathways, which form part of the MyD88-independent cellular immune response.
Comment in
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Toll signaling: the TIReless quest for specificity.Nat Immunol. 2003 Feb;4(2):105-6. doi: 10.1038/ni0203-105. Nat Immunol. 2003. PMID: 12555093 No abstract available.
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