An ultrastructural evaluation of the effect of hydrocortisone on rabbit cartilage
- PMID: 1253492
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An ultrastructural evaluation of the effect of hydrocortisone on rabbit cartilage
Clin Orthop Relat Res.
1976 Mar-Apr.
Abstract
Pharmacologic and supra-pharmacologic doses of hydrocortisone acetate did not effect ultrastructural alteration of chondrocytes in articular cartilage of mature rabbits. Early biomechanical alterations are unaccompanied by ultrastructural cytological changes. Not until advanced biochemical alteration is effected by large, repetitive doses, does the ultrastructural alteration begin.
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