The influence of HLA genotype on AIDS
- PMID: 12525683
- DOI: 10.1146/annurev.med.54.101601.152346
The influence of HLA genotype on AIDS
Abstract
Genetic resistance to infectious diseases is likely to involve a complex array of immune-response and other genes with variants that impose subtle but significant consequences on gene expression or protein function. We have gained considerable insight into the genetic determinants of HIV-1 disease, and the HLA class I genes appear to be highly influential in this regard. Numerous reports have identified a role for HLA genotype in AIDS outcomes, implicating many HLA alleles in various aspects of HIV disease. Here we review the HLA associations with progression to AIDS that have been consistently affirmed and discuss the underlying mechanisms behind some of these associations based on functional studies of immune cell recognition.
Similar articles
-
New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS.J Immunol. 1999 Jun 1;162(11):6942-6. J Immunol. 1999. PMID: 10352317
-
Associations of MHC ancestral haplotypes with resistance/susceptibility to AIDS disease development.J Immunol. 2003 Feb 15;170(4):1925-9. doi: 10.4049/jimmunol.170.4.1925. J Immunol. 2003. PMID: 12574360
-
HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.PLoS Med. 2006 Oct;3(10):e403. doi: 10.1371/journal.pmed.0030403. PLoS Med. 2006. PMID: 17076553 Free PMC article.
-
Considering genetic profiles in functional studies of immune responsiveness to HIV-1.Immunol Lett. 2001 Nov 1;79(1-2):131-40. doi: 10.1016/s0165-2478(01)00275-9. Immunol Lett. 2001. PMID: 11595300 Review.
-
Genetic predisposition to HIV-1 infection and acquired immune deficiency virus syndrome: a review of the literature examining associations with HLA [corrected].Hum Immunol. 1995 Nov;44(3):156-69. doi: 10.1016/0198-8859(95)00034-8. Hum Immunol. 1995. PMID: 8666552 Review.
Cited by
-
HIV-1 Genetic Variability and Clinical Implications.ISRN Microbiol. 2013 Jun 17;2013:481314. doi: 10.1155/2013/481314. Print 2013. ISRN Microbiol. 2013. PMID: 23844315 Free PMC article.
-
Understanding the T cell immune response in SARS coronavirus infection.Emerg Microbes Infect. 2012 Sep;1(9):e23. doi: 10.1038/emi.2012.26. Epub 2012 Sep 5. Emerg Microbes Infect. 2012. PMID: 26038429 Free PMC article. Review.
-
Derivation of HLA types from shotgun sequence datasets.Genome Med. 2012 Dec 10;4(12):95. doi: 10.1186/gm396. eCollection 2012. Genome Med. 2012. PMID: 23228053 Free PMC article.
-
Functional characterization of Vif proteins from HIV-1 infected patients with different APOBEC3G haplotypes.AIDS. 2016 Jul 17;30(11):1723-9. doi: 10.1097/QAD.0000000000001113. AIDS. 2016. PMID: 27064995 Free PMC article.
-
Do HIV-specific CTL continue to have an antiviral function during antiretroviral therapy? If not, why not, and what can be done about it?Front Immunol. 2013 Mar 1;4:52. doi: 10.3389/fimmu.2013.00052. eCollection 2013. Front Immunol. 2013. PMID: 23459829 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials