Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Jan 1;31(1):193-5.
doi: 10.1093/nar/gkg047.

MGD: the Mouse Genome Database

Judith A Blake  1 , Joel E Richardson, Carol J Bult, Jim A Kadin, Janan T Eppig; Mouse Genome Database Group
Affiliations

MGD: the Mouse Genome Database

Judith A Blake et al. Nucleic Acids Res. .

Abstract

The Mouse Genome Database (MGD) (http://www.informatics.jax.org) one component of a community database resource for the laboratory mouse, a key model organism for interpreting the human genome and for understanding human biology. MGD strives to provide an extensively integrated information resource with experimental details annotated from both literature and on-line genomic data sources. MGD curates and presents the consensus representation of genotype (sequence) to phenotype information including highly detailed information about genes and gene products. Primary foci of integration are through representations of relationships between genes, sequences and phenotypes. MGD collaborates with other bioinformatics groups to curate a definitive set of information about the laboratory mouse. Recent developments include a general implementation of database structures for controlled vocabularies and the integration of a phenotype classification system.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(A) The Allele and Phenotype Query Form permits queries based on Phenotype Classifications. In this example, the Phenotype Classification ‘tumors, increased incidence’ and Allele Type ‘Transgene induced (gene targeted)’ with only Conditional mutants returned. (B) The query presented in panel A returns a summary page of alleles defined by the criteria in A. In this case, 8 alleles met the criteria. The symbol, name and molecular description of these alleles are provided. Links are provided to the detail pages for each allele. (C) The top part of the detail page for the mutant phenotype of Brac1tm2Cxd details the Phenotype Classification terms for this particular mutation. Here, the details of the genotype that underlie the phenotype are represented. Each Phenotype Classification term is associated with one or more allele pairs and with the information known about the remaining genetic background. Thus, phenotypes are associated with genotypes, rather than simply with the allele.
See this image and copyright information in PMC

Similar articles

  • The Mouse Genome Database (MGD): integrating biology with the genome.
    Bult CJ, Blake JA, Richardson JE, Kadin JA, Eppig JT, Baldarelli RM, Barsanti K, Baya M, Beal JS, Boddy WJ, Bradt DW, Burkart DL, Butler NE, Campbell J, Corey R, Corbani LE, Cousins S, Dene H, Drabkin HJ, Frazer K, Garippa DM, Glass LH, Goldsmith CW, Grant PL, King BL, Lennon-Pierce M, Lewis J, Lu I, Lutz CM, Maltais LJ, McKenzie LM, Miers D, Modrusan D, Ni L, Ormsby JE, Qi D, Ramachandran S, Reddy TB, Reed DJ, Sinclair R, Shaw DR, Smith CL, Szauter P, Taylor B, Vanden Borre P, Walker M, Washburn L, Witham I, Winslow J, Zhu Y; Mouse Genome Database Group. Bult CJ, et al. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D476-81. doi: 10.1093/nar/gkh125. Nucleic Acids Res. 2004. PMID: 14681461 Free PMC article.
  • The Mouse Genome Database (MGD): from genes to mice--a community resource for mouse biology.
    Eppig JT, Bult CJ, Kadin JA, Richardson JE, Blake JA, Anagnostopoulos A, Baldarelli RM, Baya M, Beal JS, Bello SM, Boddy WJ, Bradt DW, Burkart DL, Butler NE, Campbell J, Cassell MA, Corbani LE, Cousins SL, Dahmen DJ, Dene H, Diehl AD, Drabkin HJ, Frazer KS, Frost P, Glass LH, Goldsmith CW, Grant PL, Lennon-Pierce M, Lewis J, Lu I, Maltais LJ, McAndrews-Hill M, McClellan L, Miers DB, Miller LA, Ni L, Ormsby JE, Qi D, Reddy TB, Reed DJ, Richards-Smith B, Shaw DR, Sinclair R, Smith CL, Szauter P, Walker MB, Walton DO, Washburn LL, Witham IT, Zhu Y; Mouse Genome Database Group. Eppig JT, et al. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D471-5. doi: 10.1093/nar/gki113. Nucleic Acids Res. 2005. PMID: 15608240 Free PMC article.
  • The Mouse Genome Database (MGD): the model organism database for the laboratory mouse.
    Blake JA, Richardson JE, Bult CJ, Kadin JA, Eppig JT; Mouse Genome Database Group. Blake JA, et al. Nucleic Acids Res. 2002 Jan 1;30(1):113-5. doi: 10.1093/nar/30.1.113. Nucleic Acids Res. 2002. PMID: 11752269 Free PMC article.
  • Mouse Genome Database: From sequence to phenotypes and disease models.
    Eppig JT, Richardson JE, Kadin JA, Smith CL, Blake JA, Bult CJ; MGD Team. Eppig JT, et al. Genesis. 2015 Aug;53(8):458-73. doi: 10.1002/dvg.22874. Epub 2015 Jul 27. Genesis. 2015. PMID: 26150326 Free PMC article. Review.
  • Mouse Genome Informatics (MGI) Is the International Resource for Information on the Laboratory Mouse.
    Law M, Shaw DR. Law M, et al. Methods Mol Biol. 2018;1757:141-161. doi: 10.1007/978-1-4939-7737-6_7. Methods Mol Biol. 2018. PMID: 29761459 Review.
See all similar articles

Cited by

See all "Cited by" articles

References

    1. Blake J.A., Eppig,J.T., Richardson,J.E., Bult,C.J., Kadin,J.A. and Mouse Genome Database Group (2002) The Mouse Genome Database (MGD): the model organism database for the laboratory mouse. Nucleic Acids Res., 30, 113–115. - PMC - PubMed
    1. Ringwald M., Eppig,J.T., Begley,D.A., Corradi,J.P., McCright,I.J., Hayamizu,T.F., Hill,D.P., Kadin,J.A. and Richardson,J.E. (2001) The mouse gene expression database. Nucleic Acids Res., 29, 98–101. - PMC - PubMed
    1. Denny P. and Justice,M.J. (2000) Mouse as the measure of man? Trends Genet., 16, 283–287. - PubMed
    1. Naf D., Krupke,D.M., Sundberg,J.P., Eppig,J.T. and Bult,C.J. (2002) The Mouse Tumor Biology Database: a public resource for cancer genetics and pathology of the mouse. Cancer Res., 62, 1235–1240. - PubMed
    1. The Gene Ontology Consortium (2001) Creating the Gene Ontology Resource: design and implementation. Genome Res., 11, 1425–1433. - PMC - PubMed

Publication types