The ubiquitin/proteasome system in Epstein-Barr virus latency and associated malignancies
- PMID: 12507558
- DOI: 10.1016/s1044-579x(02)00101-3
The ubiquitin/proteasome system in Epstein-Barr virus latency and associated malignancies
Abstract
Epstein-Barr virus (EBV) is a human herpesvirus associated with lymphoid and epithelial malignancies. Three viral proteins, the EBV nuclear antigen 1 and the latent membrane proteins-1 and -2A, regulate viral latency by manipulating ubiquitin-dependent proteolysis. The activation of cellular oncogenes is instrumental for the progression of EBV infected cells to full malignancy. Constitutively activation of c-myc correlates with decreased proteasomal activity and upregulation of compensatory proteolytic pathways in Burkitt's lymphomas. Knowledge of these multiple strategies of interference with regulated proteolysis may provide new clues for the treatment of EBV-associated malignancies.
Copyright 2002 Elsevier Science Ltd.
Similar articles
-
Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein-1: coordinate up-regulation of peptide transporters and HLA-class I antigen expression.Eur J Immunol. 1995 May;25(5):1374-84. doi: 10.1002/eji.1830250536. Eur J Immunol. 1995. PMID: 7774641
-
Three restricted forms of Epstein-Barr virus latency counteracting apoptosis in c-myc-expressing Burkitt lymphoma cells.Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14935-40. doi: 10.1073/pnas.0509988103. Epub 2006 Sep 25. Proc Natl Acad Sci U S A. 2006. PMID: 17001014 Free PMC article.
-
Epstein-Barr virus oncogenesis and the ubiquitin-proteasome system.Oncogene. 2004 Mar 15;23(11):2107-15. doi: 10.1038/sj.onc.1207372. Oncogene. 2004. PMID: 15021898 Review.
-
EBV regulates c-MYC, apoptosis, and tumorigenicity in Burkitt's lymphoma.Curr Top Microbiol Immunol. 2001;258:153-60. doi: 10.1007/978-3-642-56515-1_10. Curr Top Microbiol Immunol. 2001. PMID: 11443860 Review. No abstract available.
-
Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1.Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12616-21. doi: 10.1073/pnas.94.23.12616. Proc Natl Acad Sci U S A. 1997. PMID: 9356498 Free PMC article.
Cited by
-
p62-mediated Selective autophagy endows virus-transformed cells with insusceptibility to DNA damage under oxidative stress.PLoS Pathog. 2019 Apr 24;15(4):e1007541. doi: 10.1371/journal.ppat.1007541. eCollection 2019 Apr. PLoS Pathog. 2019. PMID: 31017975 Free PMC article.
-
Role of accessory proteins of HTLV-1 in viral replication, T cell activation, and cellular gene expression.Front Biosci. 2004 Sep 1;9:2556-76. doi: 10.2741/1417. Front Biosci. 2004. PMID: 15358581 Free PMC article. Review.
-
The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-Myc.J Virol. 2007 Oct;81(19):10451-9. doi: 10.1128/JVI.00804-07. Epub 2007 Jul 18. J Virol. 2007. PMID: 17634226 Free PMC article.
-
The Linear Ubiquitin Assembly Complex Modulates Latent Membrane Protein 1 Activation of NF-κB and Interferon Regulatory Factor 7.J Virol. 2017 Jan 31;91(4):e01138-16. doi: 10.1128/JVI.01138-16. Print 2017 Feb 15. J Virol. 2017. PMID: 27903798 Free PMC article.
-
Commentary: mechanistic considerations for associations between formaldehyde exposure and nasopharyngeal carcinoma.Environ Health. 2009 Nov 25;8:53. doi: 10.1186/1476-069X-8-53. Environ Health. 2009. PMID: 19939253 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
