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. 2002 Dec;110(12):1759-61.
doi: 10.1172/JCI17349.

A full complement of receptors in immune complex diseases

Jeffrey V Ravetch  1
Affiliations

A full complement of receptors in immune complex diseases

Jeffrey V Ravetch. J Clin Invest. 2002 Dec.
No abstract available

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Figures

Figure 1
Figure 1
IgG Fc receptors are expressed as activation/inhibitory pairs. A schematic representation of an activation receptor, FcγRIII, and its inhibitory receptor pair, FcγRII, highlight the basic principle that the interaction of two receptors with common ligand binding domains that mediate opposing signals will set a threshold for stimulation.
Figure 2
Figure 2
Regulating expression of the IgG Fc RII/RIII ratio modulates inflammatory responses. An effector cell, shown here as a macrophage, expresses both activation and inhibitory FcγRs and is capable of responding to IC or cytotoxic antibody stimulation at a defined threshold. Upregulation of the activation FcγRIII, induced by IFN-γ or C5a, results in a lowered threshold for IC stimulation and consequently an enhanced inflammatory response. Conversely, upregulation of the inhibitory FcγRII molecule by IVIG raises the threshold for IC stimulation and suppresses inflammatory responses to IgG antibodies.
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