Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus
- PMID: 12486245
- PMCID: PMC140946
- DOI: 10.1073/pnas.0135345100
Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus
Abstract
The dorsal cochlear nucleus integrates acoustic with multimodal sensory inputs from widespread areas of the brain. Multimodal inputs are brought to spiny dendrites of fusiform and cartwheel cells in the molecular layer by parallel fibers through synapses that are subject to long-term potentiation and long-term depression. Acoustic cues are brought to smooth dendrites of fusiform cells in the deep layer by auditory nerve fibers through synapses that do not show plasticity. Plasticity requires Ca(2+)-induced Ca(2+) release; its sensitivity to antagonists of N-methyl-d-aspartate and metabotropic glutamate receptors differs in fusiform and cartwheel cells.
Figures





Similar articles
-
Cell-specific, spike timing-dependent plasticities in the dorsal cochlear nucleus.Nat Neurosci. 2004 Jul;7(7):719-25. doi: 10.1038/nn1272. Epub 2004 Jun 20. Nat Neurosci. 2004. PMID: 15208632
-
Plasticity of synaptic GluN receptors is required for the Src-dependent induction of long-term potentiation at CA3-CA1 synapses.Hippocampus. 2011 Oct;21(10):1053-61. doi: 10.1002/hipo.20818. Epub 2010 Jun 2. Hippocampus. 2011. PMID: 20865743
-
Induction of homosynaptic long-term depression at spinal synapses of sensory a delta-fibers requires activation of metabotropic glutamate receptors.Neuroscience. 2000;98(1):141-8. doi: 10.1016/s0306-4522(00)00080-4. Neuroscience. 2000. PMID: 10858620
-
Mechanisms of synaptic plasticity in the dorsal cochlear nucleus: plasticity-induced changes that could underlie tinnitus.Am J Audiol. 2008 Dec;17(2):S170-5. doi: 10.1044/1059-0889(2008/07-0030). Epub 2008 Oct 31. Am J Audiol. 2008. PMID: 18978197 Free PMC article. Review.
-
What's a cerebellar circuit doing in the auditory system?Trends Neurosci. 2004 Feb;27(2):104-10. doi: 10.1016/j.tins.2003.12.001. Trends Neurosci. 2004. PMID: 15102490 Review.
Cited by
-
Stimulus-timing dependent multisensory plasticity in the guinea pig dorsal cochlear nucleus.PLoS One. 2013;8(3):e59828. doi: 10.1371/journal.pone.0059828. Epub 2013 Mar 20. PLoS One. 2013. PMID: 23527274 Free PMC article.
-
Multi-sensory integration in brainstem and auditory cortex.Brain Res. 2012 Nov 16;1485:95-107. doi: 10.1016/j.brainres.2012.08.037. Epub 2012 Aug 24. Brain Res. 2012. PMID: 22995545 Free PMC article.
-
Activation of muscarinic receptors increases the activity of the granule neurones of the rat dorsal cochlear nucleus--a calcium imaging study.Pflugers Arch. 2012 Jun;463(6):829-44. doi: 10.1007/s00424-012-1103-1. Epub 2012 May 1. Pflugers Arch. 2012. PMID: 22547003
-
Attenuation of noise-induced hyperactivity in the dorsal cochlear nucleus by pre-treatment with MK-801.Brain Res. 2018 Mar 1;1682:71-77. doi: 10.1016/j.brainres.2018.01.002. Epub 2018 Jan 9. Brain Res. 2018. PMID: 29329983 Free PMC article.
-
Learning to encode timing: mechanisms of plasticity in the auditory brainstem.Neuron. 2009 May 28;62(4):463-9. doi: 10.1016/j.neuron.2009.05.002. Neuron. 2009. PMID: 19477149 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous