Review
doi: 10.1016/s1050-1738(02)00176-7.
Cardiovascular and metabolic alterations in mice lacking beta1- and beta2-adrenergic receptors
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- PMID: 12458090
- DOI: 10.1016/s1050-1738(02)00176-7
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Review
Cardiovascular and metabolic alterations in mice lacking beta1- and beta2-adrenergic receptors
Trends Cardiovasc Med.
2002 Oct.
Abstract
Targeted disruption of murine beta-adrenergic receptor (beta-AR) genes has helped to clarify the role of specific beta-AR subtypes in regulating cardiovascular development and function. In the mouse, the beta1-AR is primarily responsible for sympathetic regulation of both cardiac chronotropy and inotropy. In contrast, all three beta-ARs play a role in regulating peripheral vascular tone. The impact of ablation of both beta1- and beta2-ARs on cardiac development and on resting cardiovascular and metabolic parameters is remarkably minimal. However, exercise stress reveals additional important contributions of beta1- and beta2-ARs to cardiovascular performance.
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