Review
The restriction point of the cell cycle
Affiliations
- PMID: 12429916
Item in Clipboard
Review
The restriction point of the cell cycle
Cell Cycle.
2002 Mar-Apr.
Abstract
As formulated in 1974, the concept of the restriction point of the cell cycle was based on cell biological experiments, yet allowing accurate molecular predictions and spurring a search for the restriction factor. Although cyclin D meets the criteria of the R-factor, the picture as outlined here is more interesting and far more complex. We discuss the relationship between the restriction knot and DNA damage-checkpoints. Finally, we discuss how loss of the restriction point in cancer leads to loss of checkpoint control and to insensitivity to antimitogens including some mechanism-based anticancer therapeutics.
Similar articles
-
Role of D1 and E cyclins in cell cycle progression of human fibroblasts adhering to cementum attachment protein.J Bone Miner Res. 2001 Jun;16(6):1062-7. doi: 10.1359/jbmr.2001.16.6.1062. J Bone Miner Res. 2001. PMID: 11393783
-
Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells.Oncogene. 2000 Mar 23;19(13):1647-56. doi: 10.1038/sj.onc.1203470. Oncogene. 2000. PMID: 10763821
-
RACK1 regulates G1/S progression by suppressing Src kinase activity.Mol Cell Biol. 2004 Aug;24(15):6788-98. doi: 10.1128/MCB.24.15.6788-6798.2004. Mol Cell Biol. 2004. PMID: 15254245 Free PMC article.
-
Regulation of cell cycle entry and G1 progression by CSF-1.Mol Reprod Dev. 1997 Jan;46(1):11-8. doi: 10.1002/(SICI)1098-2795(199701)46:1<11::AID-MRD3>3.0.CO;2-U. Mol Reprod Dev. 1997. PMID: 8981358 Review.
-
Cell cycle progression without cyclin E/CDK2: breaking down the walls of dogma.Cancer Cell. 2003 Sep;4(3):160-2. doi: 10.1016/s1535-6108(03)00217-4. Cancer Cell. 2003. PMID: 14522248 Review.
Cited by
-
How do K-RAS-activated cells evade cellular defense mechanisms?Oncogene. 2016 Feb 18;35(7):827-32. doi: 10.1038/onc.2015.153. Epub 2015 May 11. Oncogene. 2016. PMID: 25961920 Free PMC article. Review.
-
Beyond What Your Retina Can See: Similarities of Retinoblastoma Function between Plants and Animals, from Developmental Processes to Epigenetic Regulation.Int J Mol Sci. 2020 Jul 12;21(14):4925. doi: 10.3390/ijms21144925. Int J Mol Sci. 2020. PMID: 32664691 Free PMC article. Review.
-
A systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division.PLoS Genet. 2012;8(3):e1002590. doi: 10.1371/journal.pgen.1002590. Epub 2012 Mar 15. PLoS Genet. 2012. PMID: 22438835 Free PMC article.
-
Impaired DNA damage response--an Achilles' heel sensitizing cancer to chemotherapy and radiotherapy.Eur J Pharmacol. 2009 Dec 25;625(1-3):143-50. doi: 10.1016/j.ejphar.2009.05.032. Epub 2009 Oct 18. Eur J Pharmacol. 2009. PMID: 19836377 Free PMC article. Review.
-
Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblasts.Cell Commun Signal. 2021 Oct 27;19(1):105. doi: 10.1186/s12964-021-00785-0. Cell Commun Signal. 2021. PMID: 34706731 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Research Materials