TCR-independent proliferation and differentiation of human CD4+ T cell subsets induced by cytokines
- PMID: 12405193
- DOI: 10.1007/978-1-4615-0757-4_14
TCR-independent proliferation and differentiation of human CD4+ T cell subsets induced by cytokines
Abstract
Naïve and memory T cells can divide in an antigen-independent manner in vivo maintaining independently a constant pool size. While naïve T cells require TCR tickling by self-MHC for homeostatic proliferation in lymphopenic mice, memory cells do not but respond to cytokines. Human naive and memory CD4+ T cell subsets can be selectively expanded in vitro with different cytokine combinations. Responsiveness of T cells to homeostatic cytokines is associated with the differentiation state. Thus, while memory cells respond directly to IL-7 and IL-15, naïve T cells require costimulation by dendritic cell-derived cytokines, and selectively respond to IL-4. This differential cytokine responsiveness is associated with the expression and modulation of the relevant cytokine receptors. Cytokine-driven proliferation is independent of TCR-stimulation and shows distinct signal transduction requirements. While cytokine-expanded naive T cells maintain a naive phenotype, memory cells differentiate acquiring new effector functions and switching expression of chemokine receptors. Thus human naïve and memory T cell pools can be maintained with homeostatic cytokines in the absence of TCR stimulation.
Similar articles
-
Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells.J Exp Med. 2001 Dec 17;194(12):1711-9. doi: 10.1084/jem.194.12.1711. J Exp Med. 2001. PMID: 11748273 Free PMC article.
-
From naive to memory. Development and regulation of CD4+ T cell responses.Immunol Res. 1998 Aug;18(1):1-13. doi: 10.1007/BF02786509. Immunol Res. 1998. PMID: 9724845
-
Cytokine-driven proliferation and differentiation of human naïve, central memory and effector memory CD4+ T cells.Pathol Biol (Paris). 2003 Mar;51(2):64-6. doi: 10.1016/s0369-8114(03)00098-1. Pathol Biol (Paris). 2003. PMID: 12801802 Review.
-
Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human Vgamma9Vdelta2 naive, memory and effector T cell subsets.Eur J Immunol. 2005 Jun;35(6):1764-72. doi: 10.1002/eji.200525983. Eur J Immunol. 2005. PMID: 15915537
-
Cytokine synergy in antigen-independent activation and priming of naive CD8+ T lymphocytes.Crit Rev Immunol. 2009;29(3):219-39. doi: 10.1615/critrevimmunol.v29.i3.30. Crit Rev Immunol. 2009. PMID: 19538136 Review.
Cited by
-
Ex vivo stimulation of cord blood mononuclear cells by dexamethasone and interleukin-7 results in the maturation of interferon-gamma-secreting effector memory T cells.Clin Exp Immunol. 2005 Sep;141(3):440-8. doi: 10.1111/j.1365-2249.2005.02863.x. Clin Exp Immunol. 2005. PMID: 16045733 Free PMC article.
-
Interleukin-7 Unveils Pathogen-Specific T Cells by Enhancing Antigen-Recall Responses.J Infect Dis. 2018 May 25;217(12):1997-2007. doi: 10.1093/infdis/jiy096. J Infect Dis. 2018. PMID: 29506153 Free PMC article.
-
Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells.Nat Commun. 2019 May 22;10(1):2263. doi: 10.1038/s41467-019-10018-1. Nat Commun. 2019. PMID: 31118448 Free PMC article.
-
Different human resting memory CD4+ T cell subsets show similar low inducibility of latent HIV-1 proviruses.Sci Transl Med. 2020 Jan 29;12(528):eaax6795. doi: 10.1126/scitranslmed.aax6795. Sci Transl Med. 2020. PMID: 31996465 Free PMC article.
-
Biphasic regulation of Il2 transcription in CD4+ T cells: roles for TNF-alpha receptor signaling and chromatin structure.J Immunol. 2008 Jul 15;181(2):1272-81. doi: 10.4049/jimmunol.181.2.1272. J Immunol. 2008. PMID: 18606681 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
