Monoamine transporters: from genes to behavior
- PMID: 12359863
- DOI: 10.1146/annurev.pharmtox.43.050802.112309
Monoamine transporters: from genes to behavior
Abstract
Modulation of fast neurotransmission by monoamines is critically involved in numerous physiological functions and pathological conditions. Plasma membrane monoamine transporters provide one of the most efficient mechanisms controlling functional extracellular monoamine concentrations. These transporters for dopamine (DAT), serotonin (SERT), and norepinephrine (NET), which are expressed selectively on the corresponding neurons, are established targets of many psychostimulants, antidepressants, and neurotoxins. Recently, genetic animal models with targeted disruption of these transporters have become available. These mice have provided opportunities to investigate the functional importance of transporters in homeostatic control of monoaminergic transmission and to evaluate, in an in vivo model system, their roles in physiology and pathology. The use of these mice as test subjects has been helpful in resolving several important issues on specificity and mechanisms of action of certain pharmacological agents. In the present review, we summarize recent advances in understanding the physiology and pharmacology of monoamine transporters gained in mice with targeted genetic deletion of DAT, SERT, and NET.
Similar articles
-
Monoamine transporter pharmacology and mutant mice.Trends Pharmacol Sci. 2002 Aug;23(8):367-73. doi: 10.1016/s0165-6147(02)02044-8. Trends Pharmacol Sci. 2002. PMID: 12377578 Review.
-
Stimulant and reinforcing effects of cocaine in monoamine transporter knockout mice.Eur J Pharmacol. 2003 Oct 31;479(1-3):107-15. doi: 10.1016/j.ejphar.2003.08.061. Eur J Pharmacol. 2003. PMID: 14612142 Review.
-
[Function of monoamine neurotransmitter transporters].Nihon Rinsho. 2001 Aug;59(8):1457-64. Nihon Rinsho. 2001. PMID: 11519142 Review. Japanese.
-
Localization and dynamic regulation of biogenic amine transporters in the mammalian central nervous system.Front Neuroendocrinol. 1998 Jul;19(3):187-231. doi: 10.1006/frne.1998.0168. Front Neuroendocrinol. 1998. PMID: 9665836 Review.
-
Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions.Biochem Pharmacol. 2008 May 1;75(9):1835-47. doi: 10.1016/j.bcp.2008.01.014. Epub 2008 Feb 7. Biochem Pharmacol. 2008. PMID: 18329002
Cited by
-
Electrophysiological Actions of Synthetic Cathinones on Monoamine Transporters.Curr Top Behav Neurosci. 2017;32:73-92. doi: 10.1007/7854_2016_39. Curr Top Behav Neurosci. 2017. PMID: 27677783 Free PMC article.
-
Genome-Wide Identification, Characterization and Expression Analysis of the Solute Carrier 6 Gene Family in Silkworm (Bombyx mori).Int J Mol Sci. 2016 Oct 3;17(10):1675. doi: 10.3390/ijms17101675. Int J Mol Sci. 2016. PMID: 27706106 Free PMC article.
-
Inbred Lewis and Fischer 344 rat strains differ not only in novelty- and amphetamine-induced behaviors, but also in dopamine transporter activity in vivo.Brain Res. 2007 Jun 2;1151:32-45. doi: 10.1016/j.brainres.2007.03.009. Epub 2007 Mar 12. Brain Res. 2007. PMID: 17395161 Free PMC article.
-
Serotonin synthesis, release and reuptake in terminals: a mathematical model.Theor Biol Med Model. 2010 Aug 19;7:34. doi: 10.1186/1742-4682-7-34. Theor Biol Med Model. 2010. PMID: 20723248 Free PMC article.
-
Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine.PET Clin. 2009 Jan;4(1):101-28. doi: 10.1016/j.cpet.2009.05.006. PET Clin. 2009. PMID: 20216936 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
