Review
doi: 10.1126/science.1074200.
Molecular biology. Chromatin higher order folding--wrapping up transcription
Affiliations
- PMID: 12228709
- DOI: 10.1126/science.1074200
Item in Clipboard
Review
Molecular biology. Chromatin higher order folding--wrapping up transcription
Science.
.
Abstract
Eukaryotic genomes are organized into condensed, heterogeneous chromatin fibers throughout much of the cell cycle. Here we describe recent studies indicating that even transcriptionally active loci may be encompassed within 80- to 100-nanometer-thick chromonema fibers. These studies suggest that chromatin higher order folding may be a key feature of eukaryotic transcriptional control. We also discuss evidence suggesting that adenosine-5'-triphosphate-dependent chromatin-remodeling enzymes and histone-modifying enzymes may regulate transcription by controlling the extent and dynamics of chromatin higher order folding.
Similar articles
-
Changing chromatin from the inside.Nat Struct Biol. 2002 Mar;9(3):161-3. doi: 10.1038/nsb0302-161. Nat Struct Biol. 2002. PMID: 11875512 No abstract available.
-
Remodeling chromatin structures for transcription: what happens to the histones?Bioessays. 1996 Nov;18(11):875-84. doi: 10.1002/bies.950181106. Bioessays. 1996. PMID: 8939065 Review.
-
Molecular biology. A higher order of silence.Science. 2004 Nov 26;306(5701):1484-5. doi: 10.1126/science.1106767. Science. 2004. PMID: 15567842 No abstract available.
-
ATP-dependent chromatin remodeling.Curr Top Dev Biol. 2005;65:115-48. doi: 10.1016/S0070-2153(04)65004-6. Curr Top Dev Biol. 2005. PMID: 15642381 Review.
-
Influence of linker histone H1 on chromatin remodeling.Biochem Cell Biol. 2001;79(3):317-24. Biochem Cell Biol. 2001. PMID: 11467745 Review.
Cited by
-
Micro-C XL: assaying chromosome conformation from the nucleosome to the entire genome.Nat Methods. 2016 Dec;13(12):1009-1011. doi: 10.1038/nmeth.4025. Epub 2016 Oct 10. Nat Methods. 2016. PMID: 27723753
-
A complex chromatin landscape revealed by patterns of nuclease sensitivity and histone modification within the mouse beta-globin locus.Mol Cell Biol. 2003 Aug;23(15):5234-44. doi: 10.1128/MCB.23.15.5234-5244.2003. Mol Cell Biol. 2003. PMID: 12861010 Free PMC article.
-
Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens.J Mol Biol. 2007 Jun 15;369(4):917-26. doi: 10.1016/j.jmb.2007.04.004. Epub 2007 Apr 5. J Mol Biol. 2007. PMID: 17467007 Free PMC article.
-
Spurious spatial periodicity of co-expression in microarray data due to printing design.Nucleic Acids Res. 2003 Aug 1;31(15):4425-33. doi: 10.1093/nar/gkg485. Nucleic Acids Res. 2003. PMID: 12888502 Free PMC article.
-
A novel histone deacetylase inhibitor prevents IL-1beta induced metabolic dysfunction in pancreatic beta-cells.J Cell Mol Med. 2009 Aug;13(8B):1877-85. doi: 10.1111/j.1582-4934.2009.00672.x. J Cell Mol Med. 2009. PMID: 20141611 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
