The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism
- PMID: 12223315
- DOI: 10.1016/s1471-4914(02)02397-3
The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism
Abstract
MLL is a promiscuous gene involved in a diversity of chromosomal fusions in haematological malignancies, usually resulting from chromosomal translocations. MLL-associated chromosomal rearrangements usually occur in tumours of specific haematological lineages, suggesting a crucial role for the MLL fusion partner in determining disease phenotype (or tumour tropism). The MLL gene is homologous to Drosophila trithorax, and is likewise involved in embryo pattern formation. Common themes linking several of the MLL partners include a possible involvement in embryo patterning via Hox gene regulation and chromatin remodelling. These findings reinforce the link between developmental regulation and chromosomal translocations, and indicate the role of chromosomal translocation in activating genes capable of determining tumour phenotype in leukaemias and sarcomas.
Similar articles
-
The biological and clinical significance of MLL abnormalities in haematological malignancies.Eur J Clin Invest. 2004 Aug;34 Suppl 2:12-24. doi: 10.1111/j.0960-135X.2004.01366.x. Eur J Clin Invest. 2004. PMID: 15291802 Review.
-
The MLL gene and translocations involving chromosomal band 11q23 in acute leukemia.Anticancer Res. 2005 May-Jun;25(3B):1931-44. Anticancer Res. 2005. PMID: 16158928 Review.
-
Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia.Genes Chromosomes Cancer. 1997 Oct;20(2):185-95. Genes Chromosomes Cancer. 1997. PMID: 9331569
-
11q23 rearrangements in acute leukemia.Leukemia. 1996 Jan;10(1):74-82. Leukemia. 1996. PMID: 8558942 Review.
-
Acute myeloid leukemia with MLL rearrangements: clinicobiological features, prognostic impact and value of flow cytometry in the detection of residual leukemic cells.Leukemia. 2003 Jan;17(1):76-82. doi: 10.1038/sj.leu.2402708. Leukemia. 2003. PMID: 12529663
Cited by
-
Translocations in epithelial cancers.Biochim Biophys Acta. 2009 Dec;1796(2):201-15. doi: 10.1016/j.bbcan.2009.04.005. Epub 2009 May 4. Biochim Biophys Acta. 2009. PMID: 19406209 Free PMC article. Review.
-
Histone 3 lysine 4 methylation during the pre-B to immature B-cell transition.Nucleic Acids Res. 2004 Mar 29;32(6):1942-7. doi: 10.1093/nar/gkh523. Print 2004. Nucleic Acids Res. 2004. PMID: 15051812 Free PMC article.
-
Fluorescence in situ hybridization comparison of the prognostic factors in adult and pediatric acute lymphoblastic leukemia: A retrospective analysis of 282 cases.Exp Ther Med. 2018 Dec;16(6):4674-4684. doi: 10.3892/etm.2018.6821. Epub 2018 Oct 2. Exp Ther Med. 2018. PMID: 30542419 Free PMC article.
-
Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia.Mol Cell Biol. 2005 Aug;25(15):6834-45. doi: 10.1128/MCB.25.15.6834-6845.2005. Mol Cell Biol. 2005. PMID: 16024815 Free PMC article.
-
Translocation t(6;14) as the sole chromosomal abnormality in adenoid cystic carcinoma of the base of tongue.Head Neck Pathol. 2007 Dec;1(2):165-8. doi: 10.1007/s12105-007-0030-5. Epub 2007 Oct 26. Head Neck Pathol. 2007. PMID: 20614269 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
