Review
doi: 10.1161/01.hyp.0000027280.91984.1b.
Chronology versus biology: telomeres, essential hypertension, and vascular aging
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- PMID: 12215458
- DOI: 10.1161/01.hyp.0000027280.91984.1b
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Review
Chronology versus biology: telomeres, essential hypertension, and vascular aging
Hypertension.
2002 Sep.
Abstract
There is considerable evidence that essential hypertension is closely linked to the growth, development, and aging of human beings. It is imperative, therefore, to introduce biological indicators of growth and aging into models developed to provide a better understanding of the etiology of essential hypertension. One of these indicators may well be the age-dependent telomere attrition rate in somatic cells. Telomere attrition registers the replicative history of somatic cells. As such, it chronicles not only the growth that results from the replication of somatic cells but also their turnover-a process that is strongly linked to inflammation and oxidative stress, which are key factors in the biology of human aging.
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