[Efficiency and specificity of the KAT-test for rapid diagnosis of falciparum malaria]
- PMID: 12214515
[Efficiency and specificity of the KAT-test for rapid diagnosis of falciparum malaria]
Abstract
A new rapid KAT Quick Malaria test for the diagnosis of falciparum malaria, which is based on the detection of a monoclonal antibody-antigen complex of malaria parasites, has been worked out by the KAT Medical CC in South Africa. The efficiency and specificity of the KAT test were compared with those of the microscopic method and with the ICT test for rapid diagnosis of P. falciparum and P. vivax. The polymerase chain reaction was used as a control test. Testing for malaria was performed on 98 blood samples from feverish patients in Vietnam and Tadjikistan and among the persons who had returned to Moscow from endemic regions. The efficiency of the KAT test for falciparum-malaria was found to be 100% versus 90.5% with ICT. The absence of cross-reactions with P. vivax and the presence of pseudopositive results of the KAT test for fever cases of non-malaria origin indicate its high specificity. There was no correlation between the rate of test line colouring and the level of parasitemia. The KAT test yielded positive results only when gametocytes were found in blood specimens.
Similar articles
-
[Efficiency of KAT-quick P.f. test (KAT medical, SAR) among the populations of drug-resistant parasites].Med Parazitol (Mosk). 2006 Apr-Jun;(2):10-2. Med Parazitol (Mosk). 2006. PMID: 16813240 Russian.
-
Evaluation of the KAT-Quick Malaria Rapid Test for rapid diagnosis of falciparum malaria in Thailand.Southeast Asian J Trop Med Public Health. 2004 Mar;35(1):35-7. Southeast Asian J Trop Med Public Health. 2004. PMID: 15272742
-
Clinical trials of a new immunochromatographic test for diagnosis of Plasmodium falciparum malaria in Goa.Indian J Malariol. 1996 Dec;33(4):166-72. Indian J Malariol. 1996. PMID: 9125830 Clinical Trial.
-
A retrospective review of malaria cases seen in a non-endemic area of South Africa.Travel Med Infect Dis. 2008 Sep;6(5):296-300. doi: 10.1016/j.tmaid.2008.06.010. Epub 2008 Aug 15. Travel Med Infect Dis. 2008. PMID: 18760252 Review.
-
[Diagnosis of malaria in non-endemic countries : value, limitations and complementarity of existing methods].Ann Biol Clin (Paris). 2000 May-Jun;58(3):310-6. Ann Biol Clin (Paris). 2000. PMID: 10846235 Review. French.
Cited by
-
Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries.Cochrane Database Syst Rev. 2011 Jul 6;2011(7):CD008122. doi: 10.1002/14651858.CD008122.pub2. Cochrane Database Syst Rev. 2011. PMID: 21735422 Free PMC article. Review.
-
Rapid diagnostic tests for diagnosing uncomplicated non-falciparum or Plasmodium vivax malaria in endemic countries.Cochrane Database Syst Rev. 2014 Dec 18;2014(12):CD011431. doi: 10.1002/14651858.CD011431. Cochrane Database Syst Rev. 2014. PMID: 25519857 Free PMC article. Review.