doi: 10.1074/jbc.M207195200.
Epub 2002 Aug 27.
A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast
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- PMID: 12200444
- DOI: 10.1074/jbc.M207195200
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A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast
J Biol Chem.
.
Free article
Abstract
The Srb8, -9, -10, and -11 proteins of yeast have been isolated as a discrete, stoichiometric complex. The isolated complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II at serines 2 and 5. In addition to the previously reported human homologs of Srb10 and 11, we have identified TRAP230/ARC240 and TRAP240/ARC250 as the human homologs of Srb8 and Srb9, showing the entire Srb8/9/10/11 complex is conserved from yeast to humans.
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