Review
doi: 10.1038/nrc862.
Telomerase beyond telomeres
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- PMID: 12154355
- DOI: 10.1038/nrc862
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Review
Telomerase beyond telomeres
Nat Rev Cancer.
2002 Aug.
Abstract
The role of telomerase in actively proliferating cells is assumed to be restricted to maintaining of telomeres above a minimum-length threshold, thereby preventing telomere exhaustion and chromosomal instability. However, forced telomerase expression in cells and mice with normal-length telomeres has shown that telomerase promotes growth and survival in a manner that is uncoupled from net telomere lengthening. These findings imply that telomerase might have a fundamental role in tumour growth and survival, even at stages when telomeres are sufficiently long.
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