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. 2002 Aug;67(4):563-6.
doi: 10.1002/jmv.10139.

Detection and characterisation of human astroviruses in children with acute gastroenteritis in Blantyre, Malawi

Nigel A Cunliffe  1 , Winifred Dove, Jailosi S Gondwe, Benson D M Thindwa, Julie Greensill, Jennifer L Holmes, Joseph S Bresee, Stephan S Monroe, Roger I Glass, Robin L Broadhead, Malcolm E Molyneux, C Anthony Hart
Affiliations

Detection and characterisation of human astroviruses in children with acute gastroenteritis in Blantyre, Malawi

Nigel A Cunliffe et al. J Med Virol. 2002 Aug.

Abstract

In a 2-year hospital-based study of paediatric gastroenteritis in Blantyre, Malawi, astroviruses were detected by enzyme immunoassay in 15 (1.9%) of 786 inpatients and in 9 (2.3%) of 400 outpatients. Greater disease severity was noted in children coinfected with human immunodeficiency virus (HIV). Six human astrovirus (HAstV) genotypes were identified, including HAstV-1 (25%), HAstV-2 (21%), HAstV-3 (25%), HAstV-4 (13%), HAstV-5 (4%), and HAstV-8 (13%). Although astroviruses are not major causes of gastroenteritis among children admitted to hospital in Blantyre, concomitant HIV infection appears to be a risk factor for increased severity of disease.

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