Review
doi: 10.1016/s0966-842x(02)02391-0.
Virulence and pathogenesis
Affiliations
- PMID: 12110209
- DOI: 10.1016/s0966-842x(02)02391-0
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Review
Virulence and pathogenesis
Trends Microbiol.
2002 Jul.
Abstract
Why do viruses cause disease? As intracellular parasites they grow at the expense of the host, yet many infections are non-virulent. We tend to focus on unusual outcomes of infection that are important to the individual but trivial for host-parasite evolution, for example, paralytic polio or viral cancer. The assumption that the features of disease help onward transmission of the virus is true for, say, rabies, but not for AIDS or neurodegenerative diseases. Moreover, minor host differences can result in major changes in pathogen virulence. Although viral burden relates to disease severity, pathogenesis is not necessarily coupled with transmission dynamics.
Comment in
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Evolution of virulence: adaptive or not?Trends Microbiol. 2003 Mar;11(3):112-3; author reply 113-4. doi: 10.1016/s0966-842x(03)00021-0. Trends Microbiol. 2003. PMID: 12648940 No abstract available.
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