Exercise: a behavioral intervention to enhance brain health and plasticity
- PMID: 12086747
- DOI: 10.1016/s0166-2236(02)02143-4
Exercise: a behavioral intervention to enhance brain health and plasticity
Abstract
Extensive research on humans suggests that exercise could have benefits for overall health and cognitive function, particularly in later life. Recent studies using animal models have been directed towards understanding the neurobiological bases of these benefits. It is now clear that voluntary exercise can increase levels of brain-derived neurotrophic factor (BDNF) and other growth factors, stimulate neurogenesis, increase resistance to brain insult and improve learning and mental performance. Recently, high-density oligonucleotide microarray analysis has demonstrated that, in addition to increasing levels of BDNF, exercise mobilizes gene expression profiles that would be predicted to benefit brain plasticity processes. Thus, exercise could provide a simple means to maintain brain function and promote brain plasticity.
Similar articles
-
Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function.Neuroscience. 2006 Jul 7;140(3):823-33. doi: 10.1016/j.neuroscience.2006.02.084. Epub 2006 May 2. Neuroscience. 2006. PMID: 16650607
-
Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition.Eur J Neurosci. 2008 Dec;28(11):2278-87. doi: 10.1111/j.1460-9568.2008.06524.x. Eur J Neurosci. 2008. PMID: 19046371 Free PMC article.
-
Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice.Neuropsychopharmacology. 2016 Dec;41(13):3070-3079. doi: 10.1038/npp.2016.120. Epub 2016 Jul 8. Neuropsychopharmacology. 2016. PMID: 27388329 Free PMC article.
-
Exercise enhances and protects brain function.Exerc Sport Sci Rev. 2002 Apr;30(2):75-9. doi: 10.1097/00003677-200204000-00006. Exerc Sport Sci Rev. 2002. PMID: 11991541 Review.
-
Bridging animal and human models of exercise-induced brain plasticity.Trends Cogn Sci. 2013 Oct;17(10):525-44. doi: 10.1016/j.tics.2013.08.001. Epub 2013 Sep 9. Trends Cogn Sci. 2013. PMID: 24029446 Free PMC article. Review.
Cited by
-
Larger Volume and Different Activation of the Brain in Response to Threat in Military Officers.Basic Clin Neurosci. 2020 Sep-Oct;11(5):669-685. doi: 10.32598/bcn.9.10.160. Epub 2020 Sep 1. Basic Clin Neurosci. 2020. PMID: 33643560 Free PMC article.
-
Association of peak expiratory flow with motoric cognitive risk syndrome among older adults.Front Aging Neurosci. 2024 Aug 7;16:1412542. doi: 10.3389/fnagi.2024.1412542. eCollection 2024. Front Aging Neurosci. 2024. PMID: 39170900 Free PMC article.
-
Impact of Prescribed Exercise on the Physical and Cognitive Health of Adults with Down Syndrome: The MinDSets Study.Int J Environ Res Public Health. 2023 Nov 29;20(23):7121. doi: 10.3390/ijerph20237121. Int J Environ Res Public Health. 2023. PMID: 38063551 Free PMC article.
-
A hypnic hypothesis of Alzheimer's disease.Neurodegener Dis. 2013;12(4):165-76. doi: 10.1159/000350060. Epub 2013 Apr 26. Neurodegener Dis. 2013. PMID: 23635607 Free PMC article. Review.
-
Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function.Front Psychiatry. 2013 Jul 1;4:53. doi: 10.3389/fpsyt.2013.00053. eCollection 2013. Front Psychiatry. 2013. PMID: 23847550 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
