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. 2002 Jun 5;297(2):172-94.
doi: 10.1006/viro.2002.1446.

Analysis of the monkeypox virus genome

S N Shchelkunov  1 , A V Totmenin, P F Safronov, M V Mikheev, V V Gutorov, O I Ryazankina, N A Petrov, I V Babkin, E A Uvarova, L S Sandakhchiev, J R Sisler, J J Esposito, I K Damon, P B Jahrling, B Moss
Affiliations

Analysis of the monkeypox virus genome

S N Shchelkunov et al. Virology. .

Abstract

Monkeypox virus (MPV) belongs to the orthopoxvirus genus of the family Poxviridae, is endemic in parts of Africa, and causes a human disease that resembles smallpox. The 196,858-bp MPV genome was analyzed with regard to structural features and open reading frames. Each end of the genome contains an identical but oppositely oriented 6379-bp terminal inverted repetition, which similar to that of other orthopoxviruses, includes a putative telomere resolution sequence and short tandem repeats. Computer-assisted analysis was used to identify 190 open reading frames containing >/=60 amino acid residues. Of these, four were present within the inverted terminal repetition. MPV contained the known essential orthopoxvirus genes but only a subset of the putative immunomodulatory and host range genes. Sequence comparisons confirmed the assignment of MPV as a distinct species of orthopoxvirus that is not a direct ancestor or a direct descendent of variola virus, the causative agent of smallpox.

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