Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability
- PMID: 12045226
- DOI: 10.1242/jcs.115.12.2559
Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability
Abstract
Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family, comprising at least five cytokines specifically involved in the regulation of vascular and/or lymphatic endothelium differentiation. Several lines of evidence indicate a role for PlGF in monocyte chemotaxis and in potentiating the activity of VEGF, but the exact function of this cytokine is not fully understood. To define the biological role of PlGF in vivo, we have produced a transgenic mouse model overexpressing this factor in the skin by using a keratin 14 promoter cassette. Our data indicate that PlGF has strong angiogenic properties in both fetal and adult life. PlGF overexpression results in a substantial increase in the number, branching and size of dermal blood vessels as well as in enhanced vascular permeability. Indeed, intradermally injected recombinant PlGF was able to induce vessel permeability in wild-type mice. The analysis of vascular endothelial growth factor receptor 1/flt-1 and vascular endothelial growth factor receptor 2/flk-1 indicates that the two receptors are induced in the skin endothelium of transgenic mice suggesting that both are involved in mediating the effect of overexpressed PlGF.
Similar articles
-
Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1.Circ Res. 2004 Jul 23;95(2):146-53. doi: 10.1161/01.RES.0000134920.10128.b4. Epub 2004 Jun 10. Circ Res. 2004. PMID: 15192019
-
VEGFR-2-specific ligand VEGF-E induces non-edematous hyper-vascularization in mice.Biochem Biophys Res Commun. 2003 Feb 7;301(2):371-7. doi: 10.1016/s0006-291x(02)03033-4. Biochem Biophys Res Commun. 2003. PMID: 12565870
-
Altered tumor vessel maturation and proliferation in placenta growth factor-producing tumors: potential relationship to post-therapy tumor angiogenesis and recurrence.Int J Cancer. 2003 Jun 10;105(2):158-64. doi: 10.1002/ijc.11059. Int J Cancer. 2003. PMID: 12673673
-
The placenta growth factor in skin angiogenesis.J Dermatol Sci. 2006 Jan;41(1):11-9. doi: 10.1016/j.jdermsci.2005.08.008. Epub 2005 Oct 10. J Dermatol Sci. 2006. PMID: 16216466 Review.
-
Complementary actions of VEGF and angiopoietin-1 on blood vessel growth and leakage.J Anat. 2002 Jun;200(6):575-80. doi: 10.1046/j.1469-7580.2002.00061.x. J Anat. 2002. PMID: 12162725 Free PMC article. Review.
Cited by
-
Redox signaling in cardiovascular pathophysiology: A focus on hydrogen peroxide and vascular smooth muscle cells.Redox Biol. 2016 Oct;9:244-253. doi: 10.1016/j.redox.2016.08.015. Epub 2016 Aug 26. Redox Biol. 2016. PMID: 27591403 Free PMC article. Review.
-
Increased melanoma growth and metastasis spreading in mice overexpressing placenta growth factor.Am J Pathol. 2006 Aug;169(2):643-54. doi: 10.2353/ajpath.2006.051041. Am J Pathol. 2006. PMID: 16877362 Free PMC article.
-
Macrophages in Glioblastoma Development and Therapy: A Double-Edged Sword.Life (Basel). 2022 Aug 12;12(8):1225. doi: 10.3390/life12081225. Life (Basel). 2022. PMID: 36013403 Free PMC article. Review.
-
Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human.Arch Toxicol. 2018 May;92(5):1877-1891. doi: 10.1007/s00204-018-2189-9. Epub 2018 Mar 19. Arch Toxicol. 2018. PMID: 29556671 Free PMC article.
-
Deciphering c-MYC-regulated genes in two distinct tissues.BMC Genomics. 2011 Sep 30;12:476. doi: 10.1186/1471-2164-12-476. BMC Genomics. 2011. PMID: 21961992 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
