Review
doi: 10.1038/nrm827.
Adenovirus-5 E1A: paradox and paradigm
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- PMID: 12042766
- DOI: 10.1038/nrm827
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Review
Adenovirus-5 E1A: paradox and paradigm
Nat Rev Mol Cell Biol.
2002 Jun.
Abstract
The adenovirus early region 1A (E1A) proteins were described originally as immortalizing oncoproteins that altered transcription in rodent cells. Surprisingly, the 243-amino-acid form of adenovirus-5 E1A was found subsequently to reverse-transform many human tumour cells. Tumour suppression apparently results from the ability of E1A to re-programme transcription in tumour cells, and the molecular basis of this intriguing effect is now beginning to emerge. These discoveries have provided a tool with which to study the regulation of fundamental cellular processes.
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