Review
doi: 10.1006/clim.2001.5167.
Targeting monocyte recruitment in CNS autoimmune disease
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- PMID: 12027417
- DOI: 10.1006/clim.2001.5167
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Review
Targeting monocyte recruitment in CNS autoimmune disease
Clin Immunol.
2002 May.
Abstract
Monocytes and macrophages play a pathogenic role in a number of autoimmune inflammatory diseases. Recent studies in experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, have identified a critical chemokine-mediated mechanism of monocyte homing to the central nervous system (CNS). Here, we summarize the current findings in EAE, develop a rationale for targeting the chemokine axis in order to treat CNS inflammatory disease, and review currently available molecule-specific therapeutics that inhibit monocyte trafficking to the CNS.
(c) 2002 Elsevier Science (USA).
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