Review
doi: 10.1038/nrg751.
The art and design of genetic screens: Drosophila melanogaster
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- PMID: 11972155
- DOI: 10.1038/nrg751
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Review
The art and design of genetic screens: Drosophila melanogaster
Nat Rev Genet.
2002 Mar.
Abstract
The success of Drosophila melanogaster as a model organism is largely due to the power of forward genetic screens to identify the genes that are involved in a biological process. Traditional screens, such as the Nobel-prize-winning screen for embryonic-patterning mutants, can only identify the earliest phenotype of a mutation. This review describes the ingenious approaches that have been devised to circumvent this problem: modifier screens, for example, have been invaluable for elucidating signal-transduction pathways, whereas clonal screens now make it possible to screen for almost any phenotype in any cell at any stage of development.
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