Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 May;5(5):452-7.
doi: 10.1038/nn842.

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

Jean-Cosme Dodart  1 , Kelly R Bales, Kimberley S Gannon, Stephen J Greene, Ronald B DeMattos, Chantal Mathis, Cynthia A DeLong, Su Wu, Xin Wu, David M Holtzman, Steven M Paul
Affiliations

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

Jean-Cosme Dodart et al. Nat Neurosci. 2002 May.

Abstract

We have previously shown that chronic treatment with the monoclonal antibody m266, which is specific for amyloid beta-peptide (Abeta), increases plasma concentrations of Abeta and reduces Abeta burden in the PDAPP transgenic mouse model of Alzheimer's disease (AD). We now report that administration of m266 to PDAPP mice can rapidly reverse memory deficits in both an object recognition task and a holeboard learning and memory task, but without altering brain Abeta burden. We also found that an Abeta/antibody complex was present in both the plasma and the cerebrospinal fluid of m266-treated mice. Our data indicate that passive immunization with this anti-Abeta monoclonal antibody can very rapidly reverse memory impairment in certain learning and memory tasks in the PDAPP mouse model of AD, owing perhaps to enhanced peripheral clearance and (or) sequestration of a soluble brain Abeta species.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

MeSH terms