Review
doi: 10.1038/nrc703.
Helicobacter pylori and gastrointestinal tract adenocarcinomas
Affiliations
- PMID: 11902583
- DOI: 10.1038/nrc703
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Review
Helicobacter pylori and gastrointestinal tract adenocarcinomas
Nat Rev Cancer.
2002 Jan.
Abstract
Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in the stomach, only a small fraction of colonized individuals develop this common malignancy. H. pylori strain and host genotypes probably influence the risk of carcinogenesis by differentially affecting host inflammatory responses and epithelial-cell physiology. Understanding the host-microbial interactions that lead to neoplasia will improve cancer-targeted therapeutics and diagnostics, and provide mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.
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