Review
doi: 10.1016/s0959-437x(02)00282-4.
Histone H2A variants H2AX and H2AZ
Affiliations
- PMID: 11893489
- DOI: 10.1016/s0959-437x(02)00282-4
Item in Clipboard
Review
Histone H2A variants H2AX and H2AZ
Curr Opin Genet Dev.
2002 Apr.
Abstract
Two of the nucleosomal histone families, H3 and H2A, have highly conserved variants with specialized functions. Recent studies have begun to elucidate the roles of two of the H2A variants, H2AX and H2AZ. H2AX is phosphorylated on a serine four residues from the carboxyl terminus in response to the introduction of DNA double-strand breaks, whether these breaks are a result of environmental insult, metabolic mistake, or programmed process. H2AZ appears to alter nucleosome stability, is partially redundant with nucleosome remodeling complexes, and is involved in transcriptional control.
Similar articles
-
Toxoplasma H2A variants reveal novel insights into nucleosome composition and functions for this histone family.J Mol Biol. 2009 Sep 11;392(1):33-47. doi: 10.1016/j.jmb.2009.07.017. Epub 2009 Jul 14. J Mol Biol. 2009. PMID: 19607843 Free PMC article.
-
A role for Saccharomyces cerevisiae histone H2A in DNA repair.Nature. 2000 Dec 21-28;408(6815):1001-4. doi: 10.1038/35050000. Nature. 2000. PMID: 11140636
-
Structure and function of histone H2AX.Subcell Biochem. 2010;50:55-78. doi: 10.1007/978-90-481-3471-7_4. Subcell Biochem. 2010. PMID: 20012577 Review.
-
DNA double-strand break-induced phosphorylation of Drosophila histone variant H2Av helps prevent radiation-induced apoptosis.Nucleic Acids Res. 2002 Sep 1;30(17):3698-705. doi: 10.1093/nar/gkf496. Nucleic Acids Res. 2002. PMID: 12202754 Free PMC article.
-
Quickly evolving histones, nucleosome stability and chromatin folding: all about histone H2A.Bbd.Gene. 2008 Apr 30;413(1-2):1-7. doi: 10.1016/j.gene.2008.02.003. Epub 2008 Feb 16. Gene. 2008. PMID: 18329190 Review.
Cited by
-
DNA-damage accumulation and replicative arrest in Hutchinson-Gilford progeria syndrome.Biochem Soc Trans. 2011 Dec;39(6):1764-9. doi: 10.1042/BST20110687. Biochem Soc Trans. 2011. PMID: 22103522 Free PMC article. Review.
-
From 1957 to Nowadays: A Brief History of Epigenetics.Int J Mol Sci. 2020 Oct 14;21(20):7571. doi: 10.3390/ijms21207571. Int J Mol Sci. 2020. PMID: 33066397 Free PMC article. Review.
-
Maternal PCBP1 determines the normal timing of pronucleus formation in mouse eggs.Cell Mol Life Sci. 2015 Sep;72(18):3575-86. doi: 10.1007/s00018-015-1905-3. Epub 2015 Apr 17. Cell Mol Life Sci. 2015. PMID: 25894693 Free PMC article.
-
gammaH2AX foci form preferentially in euchromatin after ionising-radiation.PLoS One. 2007 Oct 24;2(10):e1057. doi: 10.1371/journal.pone.0001057. PLoS One. 2007. PMID: 17957241 Free PMC article.
-
The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken.Nucleic Acids Res. 2005 Oct 4;33(17):5633-9. doi: 10.1093/nar/gki874. Print 2005. Nucleic Acids Res. 2005. PMID: 16204459 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
