Review
doi: 10.1038/ni0302-221.
NF-kappaB at the crossroads of life and death
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- PMID: 11875461
- DOI: 10.1038/ni0302-221
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Review
NF-kappaB at the crossroads of life and death
Nat Immunol.
2002 Mar.
Abstract
The choice between life and death is one of the major events in regulation of the immune system. T cells that specifically recognize viral or bacterial antigens are selected to survive and proliferate in response to infection, whereas those that are self-reactive are eliminated via apoptosis. Even the survival of alloreactive T cells requires their proper costimulation and, when infection subsides, the activated T cells are eliminated. A major regulator of such life or death decisions is the transcription factor NF-kappaB. However, NF-kappaB cannot function alone. A variety of mechanisms exist to modulate its activity and thereby affect the ultimate outcome of a cell's fate.
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