Clinically useful monoclonal antibodies in treatment

doi:10.1136/jcp.55.2.81

Review

. 2002 Feb;55(2):81-5.

doi: 10.1136/jcp.55.2.81.

Clinically useful monoclonal antibodies in treatment

E Drewe¹, R J Powell

Affiliations

PMID: 11864998
PMCID: PMC1769580
DOI: 10.1136/jcp.55.2.81

Review

Clinically useful monoclonal antibodies in treatment

E Drewe et al. J Clin Pathol. 2002 Feb.

. 2002 Feb;55(2):81-5.

doi: 10.1136/jcp.55.2.81.

Authors

E Drewe¹, R J Powell

Affiliation

¹ Clinical Immunology Unit, Queens Medical Centre, Nottingham NG7 2UH, UK. Liz.Drewe@Nottingham.AC.UK

PMID: 11864998
PMCID: PMC1769580
DOI: 10.1136/jcp.55.2.81

Abstract

Monoclonal antibodies have been used in clinical diagnosis for many years but it is only now that these agents are being licensed for clinical treatments. This review will focus on UK licensed monoclonal antibodies highlighting their clinical benefits, limitations, and side effects.

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Figures

**Figure 1**
Diagram to show different types of monoclonal antibody molecules being developed for treatment.

See this image and copyright information in PMC

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References

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1. Scallon BJ, Moore MA, Trinh H, et al. Chimeric anti-TNFα monoclonal antibody cA2 binds recombinant transmembrane TNFα and activates immune effector functions. Cytokine 1995;7:251–9. - PubMed
1. Targan SR, Hanauer SB, Van Deventer SJH, et al. A short term study of chimeric monoclonal antibody cA2 to TNFα for Crohns disease. N Engl J Med 1997;337:1029–35. - PubMed
1. Rutgeerts P, D'Haens G, Targan S, et al. Efficacy and safety of retreatment with anti-TNF antibody (Infliximab) to maintain remission of Crohns disease. Gastroenterology 1999;117:761–9. - PubMed
1. D'Haens G, Van Deventer S, Van Hogezand R, et al. Endoscopic and histological healing with Infliximab anti-TNF antibodies in Crohns disease. Gastroenterology 1999;116:1029–34. - PubMed

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[1] Reimund JM, Wittersheim C, Dumont S, et al. Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease. J Clin Immunol 1996;16:144–50. - PubMed

[2] Reimund JM, Wittersheim C, Dumont S, et al. Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease. J Clin Immunol 1996;16:144–50. - PubMed

[3] Scallon BJ, Moore MA, Trinh H, et al. Chimeric anti-TNFα monoclonal antibody cA2 binds recombinant transmembrane TNFα and activates immune effector functions. Cytokine 1995;7:251–9. - PubMed

[4] Scallon BJ, Moore MA, Trinh H, et al. Chimeric anti-TNFα monoclonal antibody cA2 binds recombinant transmembrane TNFα and activates immune effector functions. Cytokine 1995;7:251–9. - PubMed

[5] Targan SR, Hanauer SB, Van Deventer SJH, et al. A short term study of chimeric monoclonal antibody cA2 to TNFα for Crohns disease. N Engl J Med 1997;337:1029–35. - PubMed

[6] Targan SR, Hanauer SB, Van Deventer SJH, et al. A short term study of chimeric monoclonal antibody cA2 to TNFα for Crohns disease. N Engl J Med 1997;337:1029–35. - PubMed

[7] Rutgeerts P, D'Haens G, Targan S, et al. Efficacy and safety of retreatment with anti-TNF antibody (Infliximab) to maintain remission of Crohns disease. Gastroenterology 1999;117:761–9. - PubMed

[8] Rutgeerts P, D'Haens G, Targan S, et al. Efficacy and safety of retreatment with anti-TNF antibody (Infliximab) to maintain remission of Crohns disease. Gastroenterology 1999;117:761–9. - PubMed

[9] D'Haens G, Van Deventer S, Van Hogezand R, et al. Endoscopic and histological healing with Infliximab anti-TNF antibodies in Crohns disease. Gastroenterology 1999;116:1029–34. - PubMed

[10] D'Haens G, Van Deventer S, Van Hogezand R, et al. Endoscopic and histological healing with Infliximab anti-TNF antibodies in Crohns disease. Gastroenterology 1999;116:1029–34. - PubMed

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Clinically useful monoclonal antibodies in treatment

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Clinically useful monoclonal antibodies in treatment

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