G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction
- PMID: 11858937
- DOI: 10.1016/s0898-6568(01)00239-x
G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction
Abstract
The mechanism by which G protein-coupled receptors (GPCRs) translate extracellular signals into cellular changes initially was envisioned as a simple linear model: activation of the receptor by agonist binding leads to dissociation of the heterotrimeric GTP-binding G protein into its alpha and betagamma subunits, both of which can activate or inhibit various downstream effector molecules. The plethora of recently described multidomain scaffolding proteins and accessory/chaperone molecules that interact with GPCR, including GPCR themselves as homo- or heterodimers, provides for diverse molecular mechanisms for ligand recognition, signalling specificity, and receptor trafficking. This review will summarize the recently described GPCR-interacting proteins and their individual functional roles, as understood. Implicit in the search for the functional relevance of these interactions is the expectation that enhancement or disruption of target cell-specific events could serve as highly selective therapeutic opportunities.
Similar articles
-
Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations.J Pharmacol Exp Ther. 2001 Jun;297(3):1218-26. J Pharmacol Exp Ther. 2001. PMID: 11356949
-
Transmembrane signaling by G protein-coupled receptors.Methods Mol Biol. 2006;332:3-49. doi: 10.1385/1-59745-048-0:1. Methods Mol Biol. 2006. PMID: 16878684 Review.
-
G protein-coupled receptor signalling and cross-talk: achieving rapidity and specificity.Cell Signal. 2002 May;14(5):397-405. doi: 10.1016/s0898-6568(01)00258-3. Cell Signal. 2002. PMID: 11882384 Review.
-
G protein coupled receptor dimerization: implications in modulating receptor function.J Mol Med (Berl). 2001 Jun;79(5-6):226-42. doi: 10.1007/s001090100219. J Mol Med (Berl). 2001. PMID: 11485015 Review.
-
Coupling mechanism of a GPCR and a heterotrimeric G protein during chemoattractant gradient sensing in Dictyostelium.Sci Signal. 2010 Sep 28;3(141):ra71. doi: 10.1126/scisignal.2000980. Sci Signal. 2010. PMID: 20876874
Cited by
-
Non-traditional roles of G protein-coupled receptors in basic cell biology.Mol Biosyst. 2013 Apr 5;9(4):586-95. doi: 10.1039/c2mb25429h. Mol Biosyst. 2013. PMID: 23247090 Free PMC article. Review.
-
A simple method for quantifying functional selectivity and agonist bias.ACS Chem Neurosci. 2012 Mar 21;3(3):193-203. doi: 10.1021/cn200111m. Epub 2011 Dec 20. ACS Chem Neurosci. 2012. PMID: 22860188 Free PMC article.
-
Heat shock protein 90 is an essential molecular chaperone for CB2 cannabinoid receptor-mediated signaling in trabecular meshwork cells.Mol Vis. 2012;18:2839-46. Epub 2012 Nov 29. Mol Vis. 2012. PMID: 23233786 Free PMC article.
-
Investigation of hydrophobic moment and hydrophobicity properties for transmembrane alpha-helices.Theor Biol Med Model. 2004 Aug 16;1:5. doi: 10.1186/1742-4682-1-5. Theor Biol Med Model. 2004. PMID: 15312230 Free PMC article.
-
Immunological mechanisms in specific immunotherapy.Springer Semin Immunopathol. 2004 Feb;25(3-4):377-90. doi: 10.1007/s00281-003-0147-x. Epub 2003 Oct 24. Springer Semin Immunopathol. 2004. PMID: 15007636 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
