Review
doi: 10.1016/s1074-7613(01)00261-8.
Chemokines and the tissue-specific migration of lymphocytes
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- PMID: 11825560
- DOI: 10.1016/s1074-7613(01)00261-8
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Review
Chemokines and the tissue-specific migration of lymphocytes
Immunity.
2002 Jan.
Free article
Abstract
Tissue-selective trafficking of memory and effector T and B lymphocytes is mediated by unique combinations of adhesion molecules and chemokines. The discovery of several related epithelial-expressed chemokines (TECK/CCL25 in small intestine, CTACK/CCL27 in skin, and MEC/CCL28 in diverse mucosal sites) now highlights an important role for epithelial cells in controlling homeostatic lymphocyte trafficking, including the localization of cutaneous and intestinal memory T cells, and of IgA plasma cells. Constitutively expressed epithelial chemokines may help determine the character of local immune responses and contribute to the systemic organization of the immune system.
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