[Apoptosis of renal cell carcinoma and apoptotic related genes bcl-2 and bax]
- PMID: 11825416
[Apoptosis of renal cell carcinoma and apoptotic related genes bcl-2 and bax]
Abstract
Objective: To explore the mechanism of renal cell carcinoma (RCC).
Method: We detected the apoptotic status and the expression of apoptotic related gene bcl-2 and bax protein in 48 cases of RCC with TdT-mediated dUTP-biotin nick end labeling (TUNEL) and immunohistochemistry methods.
Result: 22 cases showed low expression of bcl-2 protein with an average apoptotic index (AI) of 1.35 and 26 cases had high expression of bcl-2 with an AI of 1.04 (P < 0.05). 34 cases showed low expression of bax protein with average AI of 1.03 and 14 cases had high expression of bax protein with an average AI of 1.63 (P < 0.01). The stronger bcl-2 expression, the weaker bax expression and the less number of apoptotic cells.
Conclusion: both bcl-2 and bax take part in the occurrence and progression of RCC.
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