Comment
doi: 10.1016/s0896-6273(02)00566-4.
Surrounded by Slit--how forebrain commissural axons can be led astray
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- PMID: 11804561
- DOI: 10.1016/s0896-6273(02)00566-4
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Surrounded by Slit--how forebrain commissural axons can be led astray
Neuron.
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Free article
Abstract
In Drosophila, Slit acts as a barrier preventing roundabout expressing axons from entering the midline and sorting contralaterally from ipsilaterally projecting axons. Hutson and Chien, Plump et al., and Bagri et al. (all in this issue of Neuron) use Slit knockout mice and zebrafish astray/Robo2 mutants to show that in vertebrates, Robo/Slit function to channel axons into specific pathways and determine where decussation points occur. Ipsilaterally and contralaterally projected axons are equally affected.
Comment on
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Pathfinding and error correction by retinal axons: the role of astray/robo2.Neuron. 2002 Jan 17;33(2):205-17. doi: 10.1016/s0896-6273(01)00579-7. Neuron. 2002. PMID: 11804569
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Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system.Neuron. 2002 Jan 17;33(2):219-32. doi: 10.1016/s0896-6273(01)00586-4. Neuron. 2002. PMID: 11804570
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Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.Neuron. 2002 Jan 17;33(2):233-48. doi: 10.1016/s0896-6273(02)00561-5. Neuron. 2002. PMID: 11804571
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