Review
doi: 10.1016/s0955-0674(01)00292-7.
Dynein at the cortex
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- PMID: 11792543
- DOI: 10.1016/s0955-0674(01)00292-7
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Review
Dynein at the cortex
Curr Opin Cell Biol.
2002 Feb.
Abstract
Cytoplasmic dynein is a minus end directed microtubule motor protein with numerous functions during interphase and mitosis. Recent evidence has identified several roles mediated by a fraction of cytoplasmic dynein associated with the cell cortex. So far, these include nuclear migration, mitotic spindle orientation, and cytoskeletal reorientation during wound healing, but others are likely. The possibility that a cortically bound form of dynein might represent its most ancient evolutionary state is discussed.
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