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Review
. 2001;14(4):311-7.
doi: 10.1089/08828240152716565.

The Kaposi' s sarcoma-associated herpesvirus latency-associated nuclear antigen

T Komatsu  1 , A J Barbera, M E Ballestas, K M Kaye
Affiliations
Review

The Kaposi' s sarcoma-associated herpesvirus latency-associated nuclear antigen

T Komatsu et al. Viral Immunol. 2001.

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8), is associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (6,7,10). While the vast majority of tumor cells from these malignancies are latently infected, only a small subset of viral genes are actually expressed (5,40,47). Of these genes, the latency-associated nuclear antigen (LANA-1, LNA, or LNA1) is the only protein consistently shown to be highly expressed by in situ hybridization and immunohistochemistry (11,20,21,32). Moreover, within the past few years LANA-1 has proven to be a quite versatile protein, playing not only a pivotal role in KSHV episome persistence, but also in interacting with and influencing several cellular genes.

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