Review
doi: 10.1016/s0952-7915(01)00305-3.
The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors
Affiliations
- PMID: 11790540
- DOI: 10.1016/s0952-7915(01)00305-3
Item in Clipboard
Review
The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors
Curr Opin Immunol.
2002 Feb.
Abstract
The efficient induction of interferons alpha and beta (IFN-alpha/beta) in virus-infected cells is central to the antiviral response of a host and is regulated mainly at the level of gene transcription. Once produced, IFN-alpha/beta transmit signals to the cell interior via a specific receptor complex to induce an antiviral response. Recently, the auto-amplification mechanism of the IFN-alpha/beta system that follows viral infection has been identified. This mechanism is mediated by transcription factors of the IFN regulatory factor family and, in fact, may have evolved to render the system more robust in antiviral responses.
Similar articles
-
Crosstalk between Autophagy and Type I Interferon Responses in Innate Antiviral Immunity.Viruses. 2019 Feb 1;11(2):132. doi: 10.3390/v11020132. Viruses. 2019. PMID: 30717138 Free PMC article. Review.
-
Positive and Negative Regulation of Type I Interferons by the Human T Cell Leukemia Virus Antisense Protein HBZ.J Virol. 2017 Sep 27;91(20):e00853-17. doi: 10.1128/JVI.00853-17. Print 2017 Oct 15. J Virol. 2017. PMID: 28768861 Free PMC article.
-
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.J Virol. 2004 Oct;78(19):10636-49. doi: 10.1128/JVI.78.19.10636-10649.2004. J Virol. 2004. PMID: 15367631 Free PMC article.
-
A weak signal for strong responses: interferon-alpha/beta revisited.Nat Rev Mol Cell Biol. 2001 May;2(5):378-86. doi: 10.1038/35073080. Nat Rev Mol Cell Biol. 2001. PMID: 11331912 Review.
-
Constitutive IFN-alpha/beta signal for efficient IFN-alpha/beta gene induction by virus.Biochem Biophys Res Commun. 2001 Jul 13;285(2):518-25. doi: 10.1006/bbrc.2001.5159. Biochem Biophys Res Commun. 2001. PMID: 11444873
Cited by
-
The Role of Interferon-λ Locus Polymorphisms in Hepatitis C and Other Infectious Diseases.J Innate Immun. 2015;7(3):231-42. doi: 10.1159/000369902. Epub 2015 Jan 23. J Innate Immun. 2015. PMID: 25634147 Free PMC article. Review.
-
Porcine deltacoronavirus E protein induces interleukin-8 production via NF-κB and AP-1 activation.Vet Microbiol. 2022 Nov;274:109553. doi: 10.1016/j.vetmic.2022.109553. Epub 2022 Aug 31. Vet Microbiol. 2022. PMID: 36181744 Free PMC article.
-
Peripheral Blood Cells from Patients with Autoimmune Addison's Disease Poorly Respond to Interferons In Vitro, Despite Elevated Serum Levels of Interferon-Inducible Chemokines.J Interferon Cytokine Res. 2015 Oct;35(10):759-70. doi: 10.1089/jir.2014.0171. Epub 2015 May 15. J Interferon Cytokine Res. 2015. PMID: 25978633 Free PMC article.
-
Synergistic Effects of Toll-Like Receptor 1/2 and Toll-Like Receptor 3 Signaling Triggering Interleukin 27 Gene Expression in Chikungunya Virus-Infected Macrophages.Front Cell Dev Biol. 2022 Feb 9;10:812110. doi: 10.3389/fcell.2022.812110. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35223841 Free PMC article.
-
Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expression.J Virol. 2006 Apr;80(7):3515-22. doi: 10.1128/JVI.80.7.3515-3522.2006. J Virol. 2006. PMID: 16537619 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
